Ignite Creation Date:
2024-05-06 @ 10:02 AM
Last Modification Date:
2024-10-26 @ 12:23 PM
Study NCT ID:
NCT03145935
Status:
UNKNOWN
Last Update Posted:
2019-04-12
First Post:
2017-05-05
Brief Title:
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance
Sponsor:
Hopital Louis Pradel
Organization:
Hopital Louis Pradel
Study Overview
Official Title:
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance
Status:
UNKNOWN
Status Verified Date:
2019-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit ICU It could be interesting to predict the decrease in stroke volume when diuretics are prescribed Nevertheless no test predict a decrease of stroke volume in a context of a diuretics induced depletion Abdominal compression AC coupled with echocardiographic measurement of the stroke volume can predict fluid responsiveness and is a good tool to assess preload dependency Another point is that during depletion refilling can occur We aim to assess the diagnostic accuracy of abdominal compression to predict a decrease of the stroke volume of 15 during diuretic-induced depletion of 10 mlkg of diuresis Secondary outcome will assess the hemoconcentration during depletion to diagnose a decrease of stroke volume during diuretic induced depletion
Detailed Description:
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit ICU The pediatric intensivist has a priority to decrease unnecessary fluid load and to make the fluid balance negative in case of fluid overload Diuretics help to make the fluid balance negative but can lead to a reduction of volemia that can lead to hypovolemia Hypovolemia can induce a reduction of stroke volume and cardiac index that can alter tissue perfusion and increase organ dysfunction
It could be interesting to predict the decrease in stroke volume when diuretics are prescribed Nevertheless no test predict a decrease of stroke volume in a context of a diuretics induced depletion
The concept of preload dependency described by frank-starling is interesting in that context
Preload dependency is a state of the working heart characterized by a modification of stroke volume when a modification of preload is done Conversely no preload dependency is a state of the working heart characterized by no modification of stroke volume when a modification of preload is done
If the heart is in a state of preload dependency a reduction of preload induced by diuretics depletion might induce a reduction of stroke volume Conversely if the heart is in a state of no preload dependency a reduction of preload induced by a diuretics depletion might not induce a reduction of stroke volume Abdominal compression coupled with echocardiographic measurement of the stroke volume can predict fluid responsiveness and is a good tool to assess preload dependency
Another point is that during depletion refilling can occur Studies performed during hemodialysis have shown that refilling maintains a stable hematocrit during depletion the absence of refilling is characterized by an hemoconcentration
We aim to assess the diagnostic accuracy of abdominal compression to predict a decrease of the stroke volume of 15 during diuretic induced depletion of 10mlkg of diuresis Secondary outcome will assess the hemoconcentration during depletion to diagnose a decrease of stroke volume during diuretic induced depletion
It could be interesting to predict the decrease in stroke volume when diuretics are prescribed Nevertheless no test predict a decrease of stroke volume in a context of a diuretics induced depletion
The concept of preload dependency described by frank-starling is interesting in that context
Preload dependency is a state of the working heart characterized by a modification of stroke volume when a modification of preload is done Conversely no preload dependency is a state of the working heart characterized by no modification of stroke volume when a modification of preload is done
If the heart is in a state of preload dependency a reduction of preload induced by diuretics depletion might induce a reduction of stroke volume Conversely if the heart is in a state of no preload dependency a reduction of preload induced by a diuretics depletion might not induce a reduction of stroke volume Abdominal compression coupled with echocardiographic measurement of the stroke volume can predict fluid responsiveness and is a good tool to assess preload dependency
Another point is that during depletion refilling can occur Studies performed during hemodialysis have shown that refilling maintains a stable hematocrit during depletion the absence of refilling is characterized by an hemoconcentration
We aim to assess the diagnostic accuracy of abdominal compression to predict a decrease of the stroke volume of 15 during diuretic induced depletion of 10mlkg of diuresis Secondary outcome will assess the hemoconcentration during depletion to diagnose a decrease of stroke volume during diuretic induced depletion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None