Ignite Creation Date:
2024-05-05 @ 12:10 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00262171
Status:
UNKNOWN
Last Update Posted:
2016-04-07
First Post:
2005-12-05
Brief Title:
Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications
Sponsor:
National Health Research Institutes Taiwan
Organization:
National Health Research Institutes Taiwan
Study Overview
Official Title:
Hereditary Nonpolyposis Colorectal Cancer in Taiwan-Related Genetic Study and Clinical Applications
Status:
UNKNOWN
Status Verified Date:
2016-03
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to establish the HNPCC related information in Taiwan and to characterize relevant susceptibility genes related to colorectal cancer to provide better disease control for the high-risk people To accomplish this objective we will collect detailed information of the HNPCC patients and their families from the collaborative hospitals and relate the information to the risk of CRC in order to provide sound disease control system in Taiwan
Detailed Description:
HNPCC is an autosomal dominant disease that is clinically characterized by the development of colorectal cancer CRC at an early age mean age 44 years old Four genes have been known to be related to this hereditary disease It shows an excess of synchronous and metachronous tumors as well as a preponderance of right-sided tumors 70 Another feature has been seen among the families of the HNPCC patients is the occurrence of adenocarcinomas at other sites particularly at the endometrial ovary stomach pancreas ureter renal pelvis and skin Difficulties arise in distinguishing environmental factors and genetic predisposition for familial clustering of CRC The discovery of HNPCC germline mutations has been momentous in that it enables a clear distinction between carriers and noncarriers for those who were previously assigned a 50 risk of germline mutation The informed consent provided by patients is important for the process of familial study and the search for germline mutations these will further provide information for education and counseling HNPCC has been reported to be responsible for about 1 to 13 of all CRC The frequency of HNPCC varies by geographical areas The true incidence of HNPCC in Taiwan area is unclear From year 1995 to 2000 50 out of 450011 patients were HNPCC according to the Amsterdam I criteria MMR gene databases are crucial to understand the relationship between genotype and phenotype Kindred sharing the same mutations but living in different places will provide the information to assess the contribution of environmental factors to colorectal carcinogenesis The related clinical and basic researches are thus important for understanding the mutation spectrum of MMR genes interaction between oncogenes tumor suppressor genes and roles of genetic polymorphisms in modifying MMR genes in Taiwan
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None