Ignite Creation Date:
2024-05-05 @ 12:10 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00262613
Status:
COMPLETED
Last Update Posted:
2006-05-29
First Post:
2005-12-06
Brief Title:
Sodium Pyruvate Therapy in COPD Patients
Sponsor:
Emphycorp
Organization:
Emphycorp
Study Overview
Official Title:
Long-Term Use of Inhaled Sodium Pyruvate for the Treatment of Chronic Obstructive Pulmonary Disease
Status:
COMPLETED
Status Verified Date:
2006-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In animal models sodium pyruvate has been shown to be an effective anti-inflammatory agent and in human studies sodium pyruvate has been shown to be a bronchodilating agent Subjects with COPD are known to have inflammation in the lung and often have bronchoconstriction As such these subjects typically are on multiple therapies including steroid therapy This trial will study the effect of inhaled sodium pyruvate on inflammation and lung function in COPD subjects over a six week period
Detailed Description:
Chronic obstructive pulmonary disease COPD is a disease which involves the conducting airways of the respiratory tract and affects 5-10 of individuals in the United States The morbidity and mortality associated with this disease are increasing both in the United States and worldwide 1 The mechanisms involved in the pathogenesis of COPD are complex but it can be classified as an inflammatory disease of the airways characterized by an increase in inflammatory cells neutrophils macrophages and lymphocytes both in the bronchial mucosa and in bronchoalvaeolar lavage fluid 2 Some of the many therapeutic approaches to managing this disease include various inhaled compounds such as bronchodilators ie beta agonists and both inhaled and systemic steroid treatment The current therapies are not without adverse side effects The purpose of this study is to test the safety and therapeutic value of an endogenous compound sodium pyruvate with anti-inflammatory properties anti-oxidant in patients with COPD
Reactive oxygen species ROS such as superoxide anion free hydroxyl radical and hydrogen peroxide have been shown to be toxic to various mammalian tissue 3 including lung 4--6 and have been implicated in many human diseases 7 Anti- oxidant therapy has been shown to be effective in several animal models of inflammatory lung diseases 8-10 Sodium pyruvate is a part of the bodys natural endogenous anti-oxidant defense system It is secreted by cells readily enters cells and can react with peroxide to detoxify it 11-13 Since hydrogen peroxide is also a precursor to other ROS inhibition of it has broad anti-oxidant effects Sodium pyruvate has been shown to have protective anti-oxidant activity both in vitro 11 14-17 and in vivo 18 19
Clinically sodium pyruvate has been given to patients for a variety of disorders ranging from Friedreichs ataxia 20 to open heart operations 21 It has been administered via several routes including intravenous 20-23 topical administration for hyperkeratotic disorders 24 and in dietary supplementation 25-29 Animal model studies in rats and rabbits were conducted to assess potential adverse effects Rats were used to assess the impact of sodium pyruvate administered directly to the lungs by intratracheal injection Rat Study Rabbits were used to assess the impact of sodium pyruvate administered as an inhaled mist using a nebulizer Pyruvate Inhalation Study in Rabbits There were no adverse effects noted in the parameters which were monitored for acute lung injury histology bronchoalveolar lavage fluid content and arterial blood gas analysis In addition it was shown that the intratrachcheal administration of sodium pyruvate was beneficial in diminishing the development of acute lung injury in rats induced by bleomycin The generation of toxic oxygen radicals is believed to be a major mechanism of bleomycin lung toxicity
There are two major groups of COPD medications 1 Bronchodilator agents that inhibit the bronchoconstriction characteristic of some patients with COPD and 2 anti-inflammatory agents which inhibit the inflammatory components responsible for the airway narrowing and increased mucus production also characteristic features of patients with COPD The known anti-oxidant properties of sodium pyruvate make it an attractive compound for possible therapeutic efficacy which should have in vivo anti-inflammatory effects In addition to its possible anti-inflammatory properties we previously observed Phase I study of this compound see Phase I report acute therapeutic efficacy in patients with mild bronchial asthma The observed improvement in FEV1 at 30 minutes to 2 hours post inhalation of sodium pyruvate suggests a bronchodilator effect in these patients The mechanism of action is unclear at this time but it may be a result of the ability of inhaled sodium pyruvate to modulate reactive oxygen and nitrogen species such as H2O2 and nitric oxide NO These species have both been shown to be elevated in expired breath of patients with COPD and asthma and thus implicated in the pathogenesis 30-39 Nitric oxide has been shown to play an important role in maintaining normal physiologic homeostasis in the normal and injured lung 40-42 It has been shown to reverse acetylcholine and histamine induced bronchoconstriction and to maintain normal vascular integrity 40-42 It is possible that inhaled sodium pyruvate alters airway levels of both oxygen and nitrogen reactive species resulting in a beneficial effect
Since sodium pyruvate is endogenous has been used previously in patients had no adverse affects in our animal model studies and had no adverse effects in our acute Phase I Clinical Trial in patients with mild bronchial asthma we feel that we will be able to use it safely in this long term multiple use study in patients with COPD For safety considerations only the lowest concentration of sodium pyruvate 05mM studied previously in our single dose Safety Trial will be studied in this 3-timesday double blind placebo controlled 6 week study The total daily dose per subject will be similar to the 15mM concentration 3 doses of 05mM In addition it is approximately 3 times less than the total daily dose given to subjects who received the 50mM concentration in our Single Dose Phase I Safety Trial The proposed study is designed to address both the long term multiple dose safety aspects of inhaled sodium pyruvate as well as both the acute and long-term efficacy of the compound The acute study is designed to evaluate the possible bronchodilator effects and the long term multiple use study is designed to evaluate the anti-inflammatory properties of sodium pyruvate
Reactive oxygen species ROS such as superoxide anion free hydroxyl radical and hydrogen peroxide have been shown to be toxic to various mammalian tissue 3 including lung 4--6 and have been implicated in many human diseases 7 Anti- oxidant therapy has been shown to be effective in several animal models of inflammatory lung diseases 8-10 Sodium pyruvate is a part of the bodys natural endogenous anti-oxidant defense system It is secreted by cells readily enters cells and can react with peroxide to detoxify it 11-13 Since hydrogen peroxide is also a precursor to other ROS inhibition of it has broad anti-oxidant effects Sodium pyruvate has been shown to have protective anti-oxidant activity both in vitro 11 14-17 and in vivo 18 19
Clinically sodium pyruvate has been given to patients for a variety of disorders ranging from Friedreichs ataxia 20 to open heart operations 21 It has been administered via several routes including intravenous 20-23 topical administration for hyperkeratotic disorders 24 and in dietary supplementation 25-29 Animal model studies in rats and rabbits were conducted to assess potential adverse effects Rats were used to assess the impact of sodium pyruvate administered directly to the lungs by intratracheal injection Rat Study Rabbits were used to assess the impact of sodium pyruvate administered as an inhaled mist using a nebulizer Pyruvate Inhalation Study in Rabbits There were no adverse effects noted in the parameters which were monitored for acute lung injury histology bronchoalveolar lavage fluid content and arterial blood gas analysis In addition it was shown that the intratrachcheal administration of sodium pyruvate was beneficial in diminishing the development of acute lung injury in rats induced by bleomycin The generation of toxic oxygen radicals is believed to be a major mechanism of bleomycin lung toxicity
There are two major groups of COPD medications 1 Bronchodilator agents that inhibit the bronchoconstriction characteristic of some patients with COPD and 2 anti-inflammatory agents which inhibit the inflammatory components responsible for the airway narrowing and increased mucus production also characteristic features of patients with COPD The known anti-oxidant properties of sodium pyruvate make it an attractive compound for possible therapeutic efficacy which should have in vivo anti-inflammatory effects In addition to its possible anti-inflammatory properties we previously observed Phase I study of this compound see Phase I report acute therapeutic efficacy in patients with mild bronchial asthma The observed improvement in FEV1 at 30 minutes to 2 hours post inhalation of sodium pyruvate suggests a bronchodilator effect in these patients The mechanism of action is unclear at this time but it may be a result of the ability of inhaled sodium pyruvate to modulate reactive oxygen and nitrogen species such as H2O2 and nitric oxide NO These species have both been shown to be elevated in expired breath of patients with COPD and asthma and thus implicated in the pathogenesis 30-39 Nitric oxide has been shown to play an important role in maintaining normal physiologic homeostasis in the normal and injured lung 40-42 It has been shown to reverse acetylcholine and histamine induced bronchoconstriction and to maintain normal vascular integrity 40-42 It is possible that inhaled sodium pyruvate alters airway levels of both oxygen and nitrogen reactive species resulting in a beneficial effect
Since sodium pyruvate is endogenous has been used previously in patients had no adverse affects in our animal model studies and had no adverse effects in our acute Phase I Clinical Trial in patients with mild bronchial asthma we feel that we will be able to use it safely in this long term multiple use study in patients with COPD For safety considerations only the lowest concentration of sodium pyruvate 05mM studied previously in our single dose Safety Trial will be studied in this 3-timesday double blind placebo controlled 6 week study The total daily dose per subject will be similar to the 15mM concentration 3 doses of 05mM In addition it is approximately 3 times less than the total daily dose given to subjects who received the 50mM concentration in our Single Dose Phase I Safety Trial The proposed study is designed to address both the long term multiple dose safety aspects of inhaled sodium pyruvate as well as both the acute and long-term efficacy of the compound The acute study is designed to evaluate the possible bronchodilator effects and the long term multiple use study is designed to evaluate the anti-inflammatory properties of sodium pyruvate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None