Ignite Creation Date:
2024-05-06 @ 9:55 AM
Last Modification Date:
2024-10-26 @ 12:22 PM
Study NCT ID:
NCT03118193
Status:
COMPLETED
Last Update Posted:
2021-04-30
First Post:
2017-04-10
Brief Title:
Biomarkers of Antidepressant Resistance
Sponsor:
University Hospital Tours
Organization:
University Hospital Tours
Study Overview
Official Title:
Biomarkers of Antidepressant Resistance - BIORESA
Status:
COMPLETED
Status Verified Date:
2021-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BIORESA
Brief Summary:
According to the WHO major depressive disorders have become the second worldwide cause of disability Treatment long-term medication leads to frequent resistance up to 40
Establishing a cerebral molecular signature of depression is not feasible in humans need for cerebral samples The alternative is to use peripheral biological samples blood urine saliva
Metabolomic is the integrated and quantitative study of all the metabolites of a biological system This aims to define the metabolic status of an organism for a particular condition
Metabolites are derived from biological extracts cells tissues serum plasma urine etc and are detected by
liquid or gas chromatography coupled to mass spectrometry LC-MS GC-MS
proton nuclear magnetic resonance 1 H-NMR The biomarkers resulting from these studies have become important diagnostic criteria measured objectively and evaluated as indicators of a normal or pathological state or even predictors of treatment efficacy
This approach allows the discovery of biomarkers that best describe the status of a disease for better understanding and are usable in a context of individualized medicine with effects on clinical practice and management
Establishing a cerebral molecular signature of depression is not feasible in humans need for cerebral samples The alternative is to use peripheral biological samples blood urine saliva
Metabolomic is the integrated and quantitative study of all the metabolites of a biological system This aims to define the metabolic status of an organism for a particular condition
Metabolites are derived from biological extracts cells tissues serum plasma urine etc and are detected by
liquid or gas chromatography coupled to mass spectrometry LC-MS GC-MS
proton nuclear magnetic resonance 1 H-NMR The biomarkers resulting from these studies have become important diagnostic criteria measured objectively and evaluated as indicators of a normal or pathological state or even predictors of treatment efficacy
This approach allows the discovery of biomarkers that best describe the status of a disease for better understanding and are usable in a context of individualized medicine with effects on clinical practice and management
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None