Ignite Creation Date:
2024-05-05 @ 12:10 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00266513
Status:
TERMINATED
Last Update Posted:
2017-10-06
First Post:
2005-12-16
Brief Title:
Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States
Status:
TERMINATED
Status Verified Date:
2013-07-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study investigates gene abnormalities in Primary Immune DeficiencyPID with a goal of improving the diagnosis and treatment of patients
The specific disorders include
1 X linked hyper IgM Syndrome which is caused by an abnormality in the CD40L gene
2 NEMO associated immune deficiency which is caused by an abnormality in a gene called NEMO
3 Common variable immunodeficiency CVID which has an unknown genetic basis
4 Other disorders of immunoglobulin production
This study will
1 Better characterize the clinical features of CD40 L deficiency and NEMO associated immune deficiency and other related primary immune deficiency syndromes
2 Determine the frequency of CD40 L and Nemo abnormalities
3 Determine whether particular abnormalities in these genes are associated with more of less severe illness or with specific symptoms
4 Explore the basic mechanism by which these altered genes cause immune dysfunction
5 Identify other genes causing low immune globulin levels and related primary immune deficient states
The specific disorders include
1 X linked hyper IgM Syndrome which is caused by an abnormality in the CD40L gene
2 NEMO associated immune deficiency which is caused by an abnormality in a gene called NEMO
3 Common variable immunodeficiency CVID which has an unknown genetic basis
4 Other disorders of immunoglobulin production
This study will
1 Better characterize the clinical features of CD40 L deficiency and NEMO associated immune deficiency and other related primary immune deficiency syndromes
2 Determine the frequency of CD40 L and Nemo abnormalities
3 Determine whether particular abnormalities in these genes are associated with more of less severe illness or with specific symptoms
4 Explore the basic mechanism by which these altered genes cause immune dysfunction
5 Identify other genes causing low immune globulin levels and related primary immune deficient states
Detailed Description:
This protocol is designed to study the genetics and pathophysiology of Hyper-IgM syndrome NEMO associated immune deficiency patients with related primary immune deficiency disorders and the blood relatives of immunodeficient patients Patients will undergo evaluations that include historyphysical blood sampling genetic testing and possible tissue sampling Among the aims of this protocol are to better understand genetic factors that lead to defects in host defense and to use modern and evolving methods in molecular and cellular biology to elucidate the pathogenesis of these diseases A better understanding of primary immunodeficiency could allow for the rational development of novel therapies for such diseases and to benefit future patients but it might not benefit current patients directly Routine follow-up may occur every six months - with evaluation and blood sampling Under some circumstances we may provide treatment that relates to the immune deficiency These treatments will follow standard medical practice
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-I-0049 | None | None | None |