Ignite Creation Date:
2024-05-06 @ 9:55 AM
Last Modification Date:
2024-10-26 @ 12:21 PM
Study NCT ID:
NCT03107234
Status:
UNKNOWN
Last Update Posted:
2017-04-11
First Post:
2017-04-05
Brief Title:
Involvement of the Inositol-trisphosphate Receptor in Invasive or Migratory-type Breast Cancers
Sponsor:
Centre Hospitalier Universitaire Amiens
Organization:
Centre Hospitalier Universitaire Amiens
Study Overview
Official Title:
Involvement of the Inositol-trisphosphate Receptor in Invasive or Migratory-type Breast Cancers
Status:
UNKNOWN
Status Verified Date:
2017-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CarcIno
Brief Summary:
Breast cancer is the leading cause of female cancer and female death by cancer in France Despite the improvement in early detection and therapeutic arsenal the mortality of this cancer remains high with 11 886 deaths estimated in 2012 Breast cancer is most often a carcinoma born from the lobular or ductal epithelium and is classified In two main categories non invasive and invasive Invasive breast cancers account for 75 of the cases They are usually ductal 75 and more rarely lobular 25 The cancer cells are then no longer circumscribed to the galactophoric canals or glands but have invaded neighboring tissues If they are not treated in time these cancers can then spread the cancerous cells will then migrate either by the lymphatic vessels to reach the neighboring ganglia or through the blood vessels to give metastases in other tissues In the liver lungs and bones The mortality associated with breast cancer is not due to the growth of the primary tumor but rather to the occurrence of metastases The study of the mechanisms leading to metastatic invasion ie migration and invasion is therefore of considerable importance The development of metastases depends on the acquisition by the cancer cells of various capacities including that of being able to migrate involving a remodeling of the cytoskeleton highly dependent on the intracellular calcium Ca2 concentration Several types of signals are able to induce mobilization of Ca2 from the extracellular medium or endoplasmic reticulum ER reserves At the intracellular level some of these signals are generated by inositol 145 -trisphosphate IP3 from the activation of G protein-coupled receptors or certain receptors with tyrosine kinase activity Has been shown that the expression activity and regulation of IP3R receptors IP3Rs are involved in the cancerous processes of many tissues in particular in the phenomena of proliferation of breast cancer cells Overall altered expression and or activity of IP3Rs can be used for the survival growth proliferation and migration of cancer cells
In the laboratory the investigator showed that regulation of the expression of subtype 3 IP3R3 by 17β-estradiol E2 is involved in the growth of the human mammary cancer line MCF-7 E2 triggers the release of Ca2 in an IP3-dependent mechanism while prolonged exposure to E2 leads to an increase in the expression of IP3R3 At the same time the reduction in the expression of IP3R3 cancels the proliferative effect of E2 on MCF-7 cells More recently the investigator has established that IP3R3 regulates the proliferation of cells of the human MCF-7 mammary cancer cell line via a molecular and functional interaction with the Ca2 -dependent BKCa potassium channel The determination of IP3Rs including subtype 3 as a mediator marker of breast carcinogenesis appears to be a major clinical issue
In the laboratory the investigator showed that regulation of the expression of subtype 3 IP3R3 by 17β-estradiol E2 is involved in the growth of the human mammary cancer line MCF-7 E2 triggers the release of Ca2 in an IP3-dependent mechanism while prolonged exposure to E2 leads to an increase in the expression of IP3R3 At the same time the reduction in the expression of IP3R3 cancels the proliferative effect of E2 on MCF-7 cells More recently the investigator has established that IP3R3 regulates the proliferation of cells of the human MCF-7 mammary cancer cell line via a molecular and functional interaction with the Ca2 -dependent BKCa potassium channel The determination of IP3Rs including subtype 3 as a mediator marker of breast carcinogenesis appears to be a major clinical issue
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None