Ignite Creation Date:
2024-05-06 @ 9:53 AM
Last Modification Date:
2024-10-26 @ 12:21 PM
Study NCT ID:
NCT03099395
Status:
UNKNOWN
Last Update Posted:
2017-04-05
First Post:
2017-03-28
Brief Title:
Pattern of Repeat Cardiovascular Events During Follow-up After First Diagnosed Event-MI
Sponsor:
Uppsala University
Organization:
Uppsala University
Study Overview
Official Title:
Pattern of Repeat Cardiovascular Events During Follow-up After First Diagnosed Event-MI - PRECLUDE-MI - A Retrospective Cohort Study
Status:
UNKNOWN
Status Verified Date:
2017-04
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PRECLUDE-MI
Brief Summary:
Recurrent myocardial infarctions reinfarctions can be due to recurrence at the original treatment site the presence of untreated lesions elsewhere or in progressive lesions There are scarce published data describing the localization affected vessels and severity NSTE-ACSSTE-ACS of reinfarctions compared to the index MI eg proportion of recurrent infarctions in the previously diseased vessel in large unselected patient populations If reinfarctions are generally more severe than index MIrecurrent MIs this might have implications for choice of treatment and treatment length
Moreover data from unselected patient populations on the overall incidence patternrate of patients experiencing multiple reinfarctions is sparse Patients who experience multiple ischemic events may be a subset of patients who are poor responders to therapy There is also a possibility that patients with multiple events are less likely to have received evidence-based therapy such as coronary stenting novel and more effective antithrombotics and modern lipid lowering treatment for the initial event Poor adherence to secondary prevention measures eg low compliance to medication and adherence to cardiac rehabilitation programs may also increase the risk of recurrent events
Therefore identification of the baseline characteristics including treatment decision strategies in the setting of a myocardial infarction among such subjects may allow modifications of the clinical management strategy prior to the occurrence of subsequent ischemic events Such modifications could include providing a more intensive or additional therapy in certain patient groups or find strategies to improve patient adherence and drug compliance
A patient with reinfarctions requires more hospitalizations treatments laboratory tests and out-patient visits resulting in overall increased costs From the patient perspective recurrent events result in higher mortality and worsened quality of life
Moreover data from unselected patient populations on the overall incidence patternrate of patients experiencing multiple reinfarctions is sparse Patients who experience multiple ischemic events may be a subset of patients who are poor responders to therapy There is also a possibility that patients with multiple events are less likely to have received evidence-based therapy such as coronary stenting novel and more effective antithrombotics and modern lipid lowering treatment for the initial event Poor adherence to secondary prevention measures eg low compliance to medication and adherence to cardiac rehabilitation programs may also increase the risk of recurrent events
Therefore identification of the baseline characteristics including treatment decision strategies in the setting of a myocardial infarction among such subjects may allow modifications of the clinical management strategy prior to the occurrence of subsequent ischemic events Such modifications could include providing a more intensive or additional therapy in certain patient groups or find strategies to improve patient adherence and drug compliance
A patient with reinfarctions requires more hospitalizations treatments laboratory tests and out-patient visits resulting in overall increased costs From the patient perspective recurrent events result in higher mortality and worsened quality of life
Detailed Description:
This study will combine the SWEDEHEART registries RIKS-HIA Registry of Information and Knowledge about Swedish Heart Intensive care Admissions SCAAR Swedish Coronary Angiography and Angioplasty Registry and SEPHIA the registry for secondary prevention following coronary intensive care and the Swedish National Population Registry to obtain data regarding vital status and date of death Swedish Cause of Death Register to separate fatal from non-fatal MI the Swedish Patient Registry to obtain data on prior medical history and the Swedish Drug Registry to obtain prescribed medical treatment and filled prescriptions
The RIKS-HIA database covers all acute coronary syndrome ACS patients treated at heart intensive care units in Sweden and SCAAR entails all PCI procedures performed across all centers in Sweden
In this study the investigators will include patients with first time ever of NSTE-ACS and STE-ACS and receiving care at cardiac intensive care units and entered in the SWEDEHEART registry between 1 July 2006 and 31 December 2014 Baseline and in-hospital characteristics will be obtained including peri-procedural anti-thrombotic treatments
To assess the incidence rate and fatality of reinfarctions in a contemporary unselected MI cohort
To characterize patients with one and multiple reinfarctions during the observation period vs those without
To characterize patients with one and multiple reinfarction during the observational period vs those without
The RIKS-HIA database covers all acute coronary syndrome ACS patients treated at heart intensive care units in Sweden and SCAAR entails all PCI procedures performed across all centers in Sweden
In this study the investigators will include patients with first time ever of NSTE-ACS and STE-ACS and receiving care at cardiac intensive care units and entered in the SWEDEHEART registry between 1 July 2006 and 31 December 2014 Baseline and in-hospital characteristics will be obtained including peri-procedural anti-thrombotic treatments
To assess the incidence rate and fatality of reinfarctions in a contemporary unselected MI cohort
To characterize patients with one and multiple reinfarctions during the observation period vs those without
To characterize patients with one and multiple reinfarction during the observational period vs those without
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None