Ignite Creation Date:
2024-05-05 @ 12:09 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00268541
Status:
COMPLETED
Last Update Posted:
2007-04-20
First Post:
2005-12-21
Brief Title:
Physical Activity Insulin Resistance and Function of Fat Tissue in the Offspring of Patients With Type 2 Diabetes
Sponsor:
NHS Greater Glasgow and Clyde
Organization:
NHS Greater Glasgow and Clyde
Study Overview
Official Title:
Physical Activity Insulin Resistance and Adipose Tissue Gene Expression in the Offspring of Patients With Type 2 Diabetes
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Offspring of patients with type 2 diabetes have increased risk of developing diabetes and are typically more insulin resistant than their peers with no diabetes family history We have recently demonstrated that in contrast to their sedentary counterparts physically active offspring are not insulin resistant In the proposed controlled clinical study we will examine the effects of a moderate exercise programme on insulin resistance and other metabolic risk factors in sedentary offspring and matched control subjects We hypothesise that offspring will exhibit an augmented response to exercise thereby normalising their predisposition to an adverse metabolic profile We will also investigate expression of adipokines and other genes in adipose tissue to determine whether these contribute to the increased insulin resistance observed in offspring and whether they are influenced by exercise The results will help to determine the efficacy of exercise in normalising metabolism in offspring and will help elucidate the mechanisms involved
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| BHF Project Grant PG03145 | None | None | None |