Ignite Creation Date:
2024-05-06 @ 9:52 AM
Last Modification Date:
2024-10-26 @ 12:21 PM
Study NCT ID:
NCT03096158
Status:
COMPLETED
Last Update Posted:
2019-08-07
First Post:
2017-03-16
Brief Title:
Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery
Sponsor:
Instituto de Cardiologia do Rio Grande do Sul
Organization:
Instituto de Cardiologia do Rio Grande do Sul
Study Overview
Official Title:
Cardiac and Endothelial Function Response to Early Exercise Training CEFREET Study After Coronary Artery Bypass Surgery a Randomized Clinical Trial
Status:
COMPLETED
Status Verified Date:
2018-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CEFREET
Brief Summary:
Background Coronary artery bypass grafting CABG due to coronary artery disease CAD is one of the main surgical procedures performed in the area of cardiology Individuals undergoing CABG present sarcopenia decreased muscle strength of the lower limbs decreased respiratory muscle strength and dyspnea due to immobility in the bed and the inherent conditions of the disease itself Cardiorespiratory rehabilitation techniques are rarely used with measurement in hospitals and can greatly favor an early and effective reestablishment to this population in several parameters Objective To evaluate the effect of functional electrical stimulation FES ventilatory muscle training TREMVEN early aerobic training AERO and isometric handgrip training ISO on the functional capacity endothelial function and cardiac parameters of individuals undergoing CABG Methods In a randomized clinical trial volunteers will be allocated into four groups EEF TREMVEN AERO or ISO in the preoperative period of CABG After 48 hours postoperative midway of the surgery the protocol will begin until after hospital discharge The endpoints evaluated will be functional capacity respiratory muscle strength systolic and diastolic function arterial endothelial function inflammatory profile and plasma levels of vascular endothelial growth factor VEGF Scientific contributions Phase 1 cardiorespiratory rehabilitation with alternative interventions may provide an increase in functional capacity strengthening of respiratory muscles improvement in cardiac and endothelial functions as well as increased systemic VEGF levels myocardial revascularization and improvement of the inflammatory profile effectively forwarding the individuals to the rehabilitation phase 2
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None