Ignite Creation Date:
2024-05-06 @ 9:51 AM
Last Modification Date:
2024-10-26 @ 12:20 PM
Study NCT ID:
NCT03090763
Status:
UNKNOWN
Last Update Posted:
2017-03-27
First Post:
2017-03-20
Brief Title:
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study Micro AAA
Sponsor:
Charles University Czech Republic
Organization:
Charles University Czech Republic
Study Overview
Official Title:
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study Micro AAA
Status:
UNKNOWN
Status Verified Date:
2017-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this study is to establish whether patients with aortic aneurysm compared to general population have higher levels of selected miRNAs and whether there is significant association between the level of miRNA in circulating blood and the size of the aortic aneurysm or the risk of its rupture
Detailed Description:
Aneurysm of the abdominal and thoracic aorta represents a major cause of cardiovascular morbidity and mortality The course of this condition can stay asymptomatic for long and its first manifestation can be acute rupture of the aneurysm sac with life-threatening bleeding Detection of patients at risk and their early treatment significantly reduce the percentage of this potentially lethal complications
Aortic diseases are most often degenerative processes with a varying involvement of genetic predisposition In literature a substantial number of genes were proved to affect the metabolism of the vessel wall and to determine production of structural proteins which were associated with the vascular pathologies Pathophysiologic mechanisms of lesions of the aortic wall have not been completely understood Among other they include endothelial dysfunction chronic inflammation of the vessel wall apoptosis of smooth muscle cells and degradation of the extracellular matrix resulting in the loss of integrity of layers of the vessel wall and decrease in its strength which leads to dilation rupture or dissection Apart from mutations in genes coding the structural proteins of the vessel wall many other potential biomarkers were proposed for early diagnosis of aortic aneurysm These include microRNA miRNA one-fibre chains of non-coding ribonucleic acid which are several nucleotides long and are involved in the gene expression through the mechanism of inhibition of mRNA translation or increase in its degradation Recently association of levels of these miRNAs to presence and growth of aortic aneurysms has been described
Aortic diseases are most often degenerative processes with a varying involvement of genetic predisposition In literature a substantial number of genes were proved to affect the metabolism of the vessel wall and to determine production of structural proteins which were associated with the vascular pathologies Pathophysiologic mechanisms of lesions of the aortic wall have not been completely understood Among other they include endothelial dysfunction chronic inflammation of the vessel wall apoptosis of smooth muscle cells and degradation of the extracellular matrix resulting in the loss of integrity of layers of the vessel wall and decrease in its strength which leads to dilation rupture or dissection Apart from mutations in genes coding the structural proteins of the vessel wall many other potential biomarkers were proposed for early diagnosis of aortic aneurysm These include microRNA miRNA one-fibre chains of non-coding ribonucleic acid which are several nucleotides long and are involved in the gene expression through the mechanism of inhibition of mRNA translation or increase in its degradation Recently association of levels of these miRNAs to presence and growth of aortic aneurysms has been described
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None