Ignite Creation Date:
2024-05-06 @ 9:51 AM
Last Modification Date:
2024-10-26 @ 12:21 PM
Study NCT ID:
NCT03095937
Status:
COMPLETED
Last Update Posted:
2020-02-18
First Post:
2017-03-20
Brief Title:
Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease RHD Patients
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Different Modalities for Evaluation of Fetal Cardiac Function in Pregnant Women With Rheumatic Heart Disease RHD Patients
Status:
COMPLETED
Status Verified Date:
2020-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RHD
Brief Summary:
The goal of this study is to evaluate fetal myocardial performance in patients with heart diseases in comparison to normal pregnant patients
Detailed Description:
Cardiac diseases affect 1-4 of pregnancies of industrialized countriesand the number of patients who develop cardiac problems during pregnancy is increasing
Congenital heart diseases ischemic heart and cardiac arrhythmias are the most dominant causes In developing countries rheumatic heart disease remains prevalent Pregnancy induces haemodynamic changes with increased intravascular volume which may not only poses a risk of maternal death but also of serious morbidity such as heart failure stroke and cardiac arrhythmia
The fetus is not sparedPrevious reports revealed a significant reduction in fetal growth rates associated with maternal heart diseaseThere is also association with preterm delivery and reduced birth weight The presence of maternal cyanosis and a reduced cardiac output are the most significant predictors
Accurate and reliable measurement of fetal cardiac function could be valuable for making the diagnosis and for fetal surveillanceThe most suitable parameters for assessing fetal cardiac function will mainly be determined by the cause of the dysfunction Abnormal values of ejection fraction or cardiac output are usually found in the late stages of deterioration and therefore more sensitive parameters have been proposed for earlier diagnosis and monitoring of fetal cardiac dysfunction In most cases of cardiac dysfunction diastolic parameters such as DV or IRT are the first to be altered reflecting impaired relaxation and compliance due to a stiffer or less effective heart Similarly parameters reflecting longitudinal function such as annular displacement or velocities are typically affected in the early stages as compared to radial function such as ejection fraction
The goal of this study is to evaluate fetal myocardial performance in patients with heart diseases in comparison to normal pregnant patients
Congenital heart diseases ischemic heart and cardiac arrhythmias are the most dominant causes In developing countries rheumatic heart disease remains prevalent Pregnancy induces haemodynamic changes with increased intravascular volume which may not only poses a risk of maternal death but also of serious morbidity such as heart failure stroke and cardiac arrhythmia
The fetus is not sparedPrevious reports revealed a significant reduction in fetal growth rates associated with maternal heart diseaseThere is also association with preterm delivery and reduced birth weight The presence of maternal cyanosis and a reduced cardiac output are the most significant predictors
Accurate and reliable measurement of fetal cardiac function could be valuable for making the diagnosis and for fetal surveillanceThe most suitable parameters for assessing fetal cardiac function will mainly be determined by the cause of the dysfunction Abnormal values of ejection fraction or cardiac output are usually found in the late stages of deterioration and therefore more sensitive parameters have been proposed for earlier diagnosis and monitoring of fetal cardiac dysfunction In most cases of cardiac dysfunction diastolic parameters such as DV or IRT are the first to be altered reflecting impaired relaxation and compliance due to a stiffer or less effective heart Similarly parameters reflecting longitudinal function such as annular displacement or velocities are typically affected in the early stages as compared to radial function such as ejection fraction
The goal of this study is to evaluate fetal myocardial performance in patients with heart diseases in comparison to normal pregnant patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None