Ignite Creation Date:
2024-05-06 @ 9:48 AM
Last Modification Date:
2024-10-26 @ 12:20 PM
Study NCT ID:
NCT03087214
Status:
COMPLETED
Last Update Posted:
2019-01-08
First Post:
2017-03-08
Brief Title:
Human Movement Patterns on the Thailand-Myanmar Border
Sponsor:
University of Oxford
Organization:
University of Oxford
Study Overview
Official Title:
Movement and Migration Patterns Among a Cohort of Villagers From the Thailand-Myanmar Border
Status:
COMPLETED
Status Verified Date:
2019-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The epidemiology and ecology of malaria in humans includes complex interactions between human hosts and mosquito vectors These interactions are spatio-temporal in nature and are heavily dependent on transportation capabilities and seasonal conditions Where and when infections are acquired is not well understood in the Greater Mekong Subregion GMS where there are numerous vectors many with different behaviours and habitats For example many infections appear to be associated with forests or forest edges and some of the most important mosquito vectors in the region are forest dwellers Obsomer Defourny and Coosemans 2007 Interventions that target houses at night-time eg mosquito nets have had limited success in the GMS most likely because at least some infections are acquired during the day or outside of the home Dolan et al 1993 Luxemburger et al 1994
While overall malaria incidence in the region appears to be declining the disease remains persistent in small subregions for example along international borders joining Thailand with Myanmar It will be crucial for elimination efforts to address the persistent malaria in these regions most likely requiring the use of novel and spatially targeted approaches
Increasingly spatial data and analyses are used in disease research Linard and Tatem 2012 Pybus et al 2016 Tatem et al 2012 however most spatial analyses are at aggregate scales using data from provincial or state levels More detailed studies have a single geographic reference point per individual in the study frequently the home Mosha et al 2014 Parker et al 2015 These studies allow researchers to investigate potential clustering of cases within and between houses hotspots Bejon et al 2014 Bousema et al 2012 Mosha et al 2014 Even these detailed studies typically ignore the spaces in which people spend time outside of their home and where they may acquire infection schools places of worship and work forest camps and temporary shelters Given that many malaria infections in the GMS are acquired outside of the home in areas that are not usually mapped this information is important for developing strategies to prevent transmission and will be crucial for achieving elimination
Researchers in other substantive areas have already begun mapping the movement patterns of study subjects so that exposure to a variety of environmental exposures outside of the home can be assessed Matthews and Yang 2013 Vazquez-Prokopec et al 2010 Early approaches relied on travel surveys or travel diaries both having bias of unknown magnitude Modern wearable global positioning satellite GPS instruments loggers or trackers and geographic information science GIS enable detailed mapping and quantification of human movement patterns Through analysing differences in the movement patterns between humans who do versus those that do not acquire infectious diseases it may be possible to identify a narrower set of geographic spaces in which disease transmission is occurring Public health interventions could then target those risk areas
Most of these detailed studies have been done in economically developed settings and urban environments Infectious diseases such as malaria remain persistent in resource-poor rural and remote areas - the very regions that are least likely to be studied with detailed approaches Sachs and Malaney 2002
While overall malaria incidence in the region appears to be declining the disease remains persistent in small subregions for example along international borders joining Thailand with Myanmar It will be crucial for elimination efforts to address the persistent malaria in these regions most likely requiring the use of novel and spatially targeted approaches
Increasingly spatial data and analyses are used in disease research Linard and Tatem 2012 Pybus et al 2016 Tatem et al 2012 however most spatial analyses are at aggregate scales using data from provincial or state levels More detailed studies have a single geographic reference point per individual in the study frequently the home Mosha et al 2014 Parker et al 2015 These studies allow researchers to investigate potential clustering of cases within and between houses hotspots Bejon et al 2014 Bousema et al 2012 Mosha et al 2014 Even these detailed studies typically ignore the spaces in which people spend time outside of their home and where they may acquire infection schools places of worship and work forest camps and temporary shelters Given that many malaria infections in the GMS are acquired outside of the home in areas that are not usually mapped this information is important for developing strategies to prevent transmission and will be crucial for achieving elimination
Researchers in other substantive areas have already begun mapping the movement patterns of study subjects so that exposure to a variety of environmental exposures outside of the home can be assessed Matthews and Yang 2013 Vazquez-Prokopec et al 2010 Early approaches relied on travel surveys or travel diaries both having bias of unknown magnitude Modern wearable global positioning satellite GPS instruments loggers or trackers and geographic information science GIS enable detailed mapping and quantification of human movement patterns Through analysing differences in the movement patterns between humans who do versus those that do not acquire infectious diseases it may be possible to identify a narrower set of geographic spaces in which disease transmission is occurring Public health interventions could then target those risk areas
Most of these detailed studies have been done in economically developed settings and urban environments Infectious diseases such as malaria remain persistent in resource-poor rural and remote areas - the very regions that are least likely to be studied with detailed approaches Sachs and Malaney 2002
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None