Ignite Creation Date:
2024-05-06 @ 9:48 AM
Last Modification Date:
2024-10-26 @ 12:19 PM
Study NCT ID:
NCT03076307
Status:
COMPLETED
Last Update Posted:
2017-07-21
First Post:
2017-03-06
Brief Title:
DAT SPECT and Procedural Motor Skills in Parkinsons Disease
Sponsor:
University Hospital Geneva
Organization:
University Hospital Geneva
Study Overview
Official Title:
Correlation of Procedural Motor Skills Impairment and 123I-FP-CIT SPECT Uptake in Patients With Early Parkinsons Disease a Case-control Study
Status:
COMPLETED
Status Verified Date:
2017-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with Parkinsons disease PD are known to be affected by subtle cognitive impairment early in the disease course mostly in the executive field Procedural motor skills mainly controlled by the basal ganglia associative loop in particular dorsal caudate nucleus Rodriguez-Oroz et al 2009 have also been studied in patients with PD Schnider et al 1995 Muslimovic et al 2007 Terpening et al 2013 However the correlation of dopaminergic 123I-FP-CIT SPECT imaging and cognitive impairment has not been assessed One reason is the absence of reference values for striatal uptake until recently Last year the investigators established local uptake reference values for DAT imaging based on a large cohort of subjects with non-degenerative conditions Nicastro et al 2016 and can therefore use these values to precisely assess uptake loss in patients with PD
With the present study the investigators expect to enroll patients with early PD for whom a 123I-FP-CIT SPECT has been previously performed in the center Subjects will perform a specific motor task based on mirror-drawing of star-shaped figures This will be done by inverting the direction of horizontalvertical computer mouse movements on the screen Speed and error rates will be assessed for patients as well as healthy control subjects Correlation with striatal SPECT uptake especially caudate nucleus uptake will be analyzed for PD patients In addition resting-state EEG will be performed for all subjects General medication and dopaminergic drugs in particular whenever used will not be discontinued For all subjects enrolled in the study cognitive and neurological examination will be performed
With the present study the investigators expect to enroll patients with early PD for whom a 123I-FP-CIT SPECT has been previously performed in the center Subjects will perform a specific motor task based on mirror-drawing of star-shaped figures This will be done by inverting the direction of horizontalvertical computer mouse movements on the screen Speed and error rates will be assessed for patients as well as healthy control subjects Correlation with striatal SPECT uptake especially caudate nucleus uptake will be analyzed for PD patients In addition resting-state EEG will be performed for all subjects General medication and dopaminergic drugs in particular whenever used will not be discontinued For all subjects enrolled in the study cognitive and neurological examination will be performed
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None