Ignite Creation Date:
2024-05-05 @ 12:09 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00258726
Status:
TERMINATED
Last Update Posted:
2010-08-27
First Post:
2005-11-23
Brief Title:
Immune Responses to Two Dose Varivax - MMR-II
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institute of Allergy and Infectious Diseases NIAID
Study Overview
Official Title:
Immunogenicity and Safety of Live Attenuated Varicella Vaccine in 12 and 18 Month-old Children With and Without Concomitant Administration of Measles-Mumps-Rubella Vaccine
Status:
TERMINATED
Status Verified Date:
2010-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will test the safety and how well the bodys immune system responds to a live but weakened varicella chickenpox vaccine known as Varivax given with and without ProQuad another measles mumps rubella and varicella virus vaccine MMR-II One hundred five healthy children will be enrolled in the study when they are 12 months old All subjects will be vaccinated at 12 months of age and some subjects will receive a second vaccination at 18 months of age All subjects will participate for 1 year This study is a single-site two-year trial with post-licensure vaccines
Detailed Description:
This clinical trial is a phase III exploratory immunogenicity and safety study of live attenuated Varicella Varivax Measles-Mumps-Rubella MMR-II or combination VaricellaMeasles MumpsRubella Pro-Quad vaccines administered to healthy children at 12 and 18 months of age A total of 105 healthy children 12 months old at the time of study entry will be recruited from the Palo Alto Medical Foundation clinics in Palo Alto Fremont and Los Altos California The study is designed to focus on time of primary Varivax immunization and immunologic benefits of a two-dose vaccine regimen compared to a single Varivax dose In addition the investigators will evaluate the use of Varivax with and without concomitant administration of the MMR-II further measuring immunologic responses to a two-dose MMR-II regimen The first study objective is to determine the immunogenicity of one dose of Varivax administered at 12 versus 18 months of age Participants will receive either MMR vaccine and Varivax or ProQuad depending on availability of the vaccines Immunogenicity to be measured as humoral responses utilizing plaque reduction neutralization PRN assay for measles and gpELISA for varicella antibodies and T cell immunity determined by flow cytometric T cell assays The second study objective is to determine the immunogenicity of administering two doses of Varivax and MMR-II to children at 12 and 18 months of age compared with children receiving one dose of MMR-II at 12 months and one dose of Varivax at 12 or 18 months of age Participants will receive either MMR vaccine and Varivax or ProQuad depending on availability of the vaccines The third study objective is to determine the safety of administering two doses of Varivax and MMR-II to children at 12 and 18 months of age Participants will receive either MMR vaccine and Varivax or ProQuad depending on availability of the vaccine Study personnel with documentation of all adverse events and serious adverse events will monitor safety using parental memory aids and telephone follow-up The investigators hypothesize that infants receiving Varivax or ProQuad at 12 months of age will have comparable humoral immune responses to infants receiving the vaccine at 18 months of age but that T cell immunity will be higher in those vaccinated at 18 months of age In addition infants receiving 2 doses of Varivax or ProQuad will have higher humoral and cell mediated immune responses compared with children receiving only one dose of Varivax or ProQuad This hypothesis would explain the post-licensure observations that breakthrough disease is higher in those vaccinated at 12 versus 15 months of age and in children who received one vaccination compared with two The investigators predict that there will be no differences in the humoral immune responses when measles is given concomitantly with Varivax compared to Varivax alone but the immunosuppressive effects of the measles virus can influence effects on T cell immunity It is expected that two doses of Varivax or Proquad will be well tolerated and that there will be fewer systemic adverse reactions after the second dose The Varivax package insert reports that the incidence of injection site redness and swelling was slightly higher post dose 2 but the incidence of systemic clinical complaints was lower post dose 2 The incidence of adverse experiences both locally and systemically following a second dose of ProQuad was equal to or less than those reactions seen after the first dose The investigators will evaluate the incidence of injection site reactogenicity to confirm these findings
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None