Ignite Creation Date:
2024-05-06 @ 9:47 AM
Last Modification Date:
2024-10-26 @ 12:20 PM
Study NCT ID:
NCT03077711
Status:
COMPLETED
Last Update Posted:
2020-01-14
First Post:
2017-02-27
Brief Title:
Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs
Sponsor:
NorthShore University HealthSystem
Organization:
NorthShore University HealthSystem
Study Overview
Official Title:
Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs
Status:
COMPLETED
Status Verified Date:
2020-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Several methods are available for use in the prevention of recurrent urinary tract infections UTIs over the past few decades These methods include suppressive antibiotics estrogen cream methenamine hippurate d-mannose cranberry probiotics and vitamin C Of these the majority of the literature is in favor of use of suppressive antibiotics for preventing UTIs However this data is now about 10 years old Increasing use of antibiotics over the years has lead to increased resistance of bacteria In addition long-term antibiotic use has several adverse effects some life-threatening There is recent literature evaluating the use of several of the alternatives to suppressive antibiotics with mixed results A comparative study of the efficacy of methenamine hippurate to suppressive antibiotics is lacking in the current literature Several early partly-randomized trials done with methenamine hippurate have shown promising results but are only as recent as 1987 The primary objective of this prospective randomized study is to determine whether there is a significant difference in the prevention of recurrent UTIs when given either methenamine hippurate or daily suppressive antibiotics The secondary objective of this study is to determine how well patients are able to tolerate each of these medications and what adverse effects are observed in a given 1 year time period The long-term goals of this study are to find an alternative to using suppressive antibiotics potentially with a lower adverse effect profile and less of the dangers of long term antibiotic use Finding an alternative to suppressive antibiotics would also tackle the issue of antibiotic resistance
Detailed Description:
Hypothesis
The hypothesis of this study is that the group taking trimethoprim will have a lower recurrence rate than those taking methenamine hippurate based on the literature The investigators aim to identify to what degree that difference is and whether or not it is an acceptable difference given the greater degree of an antibiotic resistance
Objectives
The primary objective of this prospective randomized study is to determine whether there is a significant difference in the prevention of recurrent UTIs when given either methenamine hippurate or daily suppressive antibiotics independent of vaginal estrogen use
The secondary objective of this study is to determine how well patients are able to tolerate each of these medications and what adverse effects are observed in a 1 year time period
Specific Aims
1 Identify if there is a differential impact on prevention of recurrent UTIs when treated with either trimethoprim or methenamine hippurate in a 6 and 12 month period
2 Identify adverse reactions in each group
3 Determine whether or not estrogen has a more additive effect to trimethoprim or methenamine hippurate in post-menopausal women
4 Identify how well tolerated the study medications are and whether or not the size of the pills or the frequency of taking them prevents patients from continuing therapy
The hypothesis of this study is that the group taking trimethoprim will have a lower recurrence rate than those taking methenamine hippurate based on the literature The investigators aim to identify to what degree that difference is and whether or not it is an acceptable difference given the greater degree of an antibiotic resistance
Objectives
The primary objective of this prospective randomized study is to determine whether there is a significant difference in the prevention of recurrent UTIs when given either methenamine hippurate or daily suppressive antibiotics independent of vaginal estrogen use
The secondary objective of this study is to determine how well patients are able to tolerate each of these medications and what adverse effects are observed in a 1 year time period
Specific Aims
1 Identify if there is a differential impact on prevention of recurrent UTIs when treated with either trimethoprim or methenamine hippurate in a 6 and 12 month period
2 Identify adverse reactions in each group
3 Determine whether or not estrogen has a more additive effect to trimethoprim or methenamine hippurate in post-menopausal women
4 Identify how well tolerated the study medications are and whether or not the size of the pills or the frequency of taking them prevents patients from continuing therapy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None