Ignite Creation Date:
2024-05-05 @ 12:09 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00258570
Status:
RECRUITING
Last Update Posted:
2023-11-14
First Post:
2005-11-23
Brief Title:
Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis IPF
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis
Status:
RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GP
Brief Summary:
The purposes of this study are
to determine if there are specific genetic traits that might explain why patients have developed pulmonary fibrosis
to determine if specific genetic traits account for differing patterns of inflammation and scar tissue that has formed in the patients lungs
to determine if there are specific genetic traits that might explain why patients have developed pulmonary fibrosis
to determine if specific genetic traits account for differing patterns of inflammation and scar tissue that has formed in the patients lungs
Detailed Description:
Idiopathic pulmonary fibrosis IPF is a disease of unknown etiology that is characterized by the insidious development of lung fibrosis ultimately leading to distortion of the lung architecture respiratory failure and death IPF is one of several entities associated with pulmonary fibrosis called the idiopathic interstitial pneumonias IIP Based on the histopathologic features of the fibrotic process it is possible to identify four distinct entities usual interstitial pneumonia UIP synonymous with IPF nonspecific interstitial pneumonia NSIP desquamative interstitial pneumonia DIP and acute interstitial pneumonia AIP Hamman-Rich lung Each type appears to have different clinical progression and a different response to anti-inflammatory therapy Our overall objective is to elucidate the molecular pathogenesis of IPF UIP by identifying factors that determine host susceptibility to this disease We hypothesize that patients who develop pulmonary fibrosis have a genetic propensity to abnormal lung repair that leads to fibrosis after acute lung injury We further hypothesize that these genetic susceptibilities may determine if the pathologic process in the lung after an insult becomes UIP AIP NSIP or DIP To explore these hypotheses we propose to characterize the genetic polymorphisms in candidate genes involved in inflammation matrix turnover fibroblast proliferation and differentiation and epithelial cell proliferation and to correlate this with indices of disease progression
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None