Ignite Creation Date:
2024-05-06 @ 9:45 AM
Last Modification Date:
2024-10-26 @ 12:19 PM
Study NCT ID:
NCT03064295
Status:
RECRUITING
Last Update Posted:
2023-02-08
First Post:
2017-02-15
Brief Title:
Whole-Heart Myocardial Blood Flow Quantification Using MRI
Sponsor:
Cedars-Sinai Medical Center
Organization:
Cedars-Sinai Medical Center
Study Overview
Official Title:
Whole-Heart Myocardial Blood Flow Quantification Using Magnetic Resonance Imaging
Status:
RECRUITING
Status Verified Date:
2023-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study hopes to provide significant technical improvement in a Myocardial Blood Flow MBF cardiac magnetic resonance CMR quantification technique to address challenges and technical limitations for MBF CMR By developing and validating novel techniques to improve first-pass perfusion FPP cardiac MR we propose to increase diagnostic accuracy by minimizing false positives and false negatives allow for better evaluation and accurate quantification of total ischemic burden and reduce image and motion-induced artifacts
The broad long-term objective of the proposed project is to improve the prognosis of patients with myocardial ischemia caused by coronary artery disease CAD or coronary microvascular dysfunction CMD
The broad long-term objective of the proposed project is to improve the prognosis of patients with myocardial ischemia caused by coronary artery disease CAD or coronary microvascular dysfunction CMD
Detailed Description:
All subjects will receive cardiac MRI scans to diagnose CAD or CMD MR perfusion scans will be performed twice per subject once at rest and once after administration of a pharmacologic stress agent There will be a 15 minute delay between the two scans A gadolinium-based contrast agent will be administered during each scan to allow measurement of myocardial blood flow Once myocardial blood flow is quantified the measurements will be compared to previous reference measurements when available from PET myocardial perfusion imaging in the CAD patient cohort and coronary reactivity testing CRT in the CMD patient cohort
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01HL124649 | NIH | None | httpsreporternihgovquickSearch1R01HL124649 |