Ignite Creation Date:
2024-05-05 @ 12:08 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00250718
Status:
TERMINATED
Last Update Posted:
2015-08-03
First Post:
2005-11-04
Brief Title:
Study Treatment of Relapsed Lymphoid Malignancies With an Anti-Angiogenic Approach
Sponsor:
New Mexico Cancer Care Alliance
Organization:
New Mexico Cancer Care Alliance
Study Overview
Official Title:
Phase II Study Treatment of Relapsed Lymphoid Malignancies With an Anti-angiogenic Approach
Status:
TERMINATED
Status Verified Date:
2015-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Low rate of accrual
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
11 To determine the efficacy of a combination treatment of VP-16 chlorambucil dexamethasone and vincristine in patients with relapsedrefractory hematological malignancies
12 To determine the toxicity profile of the above regimen in this patient population
13 Evaluate the effect of low dose administration of chemotherapy on angiogenesis and correlate this with tumor responses
12 To determine the toxicity profile of the above regimen in this patient population
13 Evaluate the effect of low dose administration of chemotherapy on angiogenesis and correlate this with tumor responses
Detailed Description:
The purpose of the study is to see how effective the combination of chemotherapy drugs VP-16 chlorambucil dexamethasone and vincristine is for patients who have blood cancers that have returned or not responded to prior treatment Some patients may also receive a medication called rituximab if their doctor thinks it is appropriate This drug combination will be given to study participants in a low dose continuous basis The study will also collect information about the side effects of the above drug combination on patients with these types of cancers Previous studies on patients with non-Hodgkins lymphoma indicate that some patients treated with this drug combination achieved a high response The aim of this study is to test this drug combination in a controlled setting
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None