Ignite Creation Date:
2024-05-05 @ 12:08 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00253929
Status:
COMPLETED
Last Update Posted:
2007-04-05
First Post:
2005-11-11
Brief Title:
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
Sponsor:
Radboud University Medical Center
Organization:
Radboud University Medical Center
Study Overview
Official Title:
The Influence of the 1976TC Polymorphism in the Adenosine A2A Receptor Gene on Adenosine-Induced Vasodilation and the Influence of the 34CT Polymorphism in the AMP Deaminase Gene on Post-Occlusive Reactive Hyperemia
Status:
COMPLETED
Status Verified Date:
2006-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors taken together these effects protect against ischaemia-reperfusion injury of myocardialmuscles and agsinst the development of atherosclerosis Genetic variations in genes encoding for adenosine receptors or for enzymes involved in the formation or breakdown of adenosine could potentially modulate these effects In this study we aim to determine the functional effects of two frequent genetic polymorphisms in the adenosine receptor and AMPdeaminase involved in the formation of adenosine on the vascular effects of adenosine
Detailed Description:
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors taken together these effects protect against ischaemia-reperfusion injury of myocardialmuscles and agsinst the development of atherosclerosis Genetic variations in genes encoding for adenosine receptors or for enzymes involved in the formation or breakdown of adenosine could potentially modulate these effects In this study we aim to determine the functional effects of two frequent genetic polymorphisms in the adenosine receptor and AMPdeaminase involved in the formation of adenosine on the vascular effects of adenosine
In 100 healthy young volunteers we will determine the genotype of the adenosine A2A receptor gene We expect to find approximately 15 subjects with the 1976TC polymorphisms It is known that this polymorphism is associated with an increased neuropsychological sensitivity to caffeine administration
We will explore whether this polymorphism is associated with a different vasodilating response to the administration of adenosine and caffeine into the brachial artery Blood flow will be measured with venous occlucion plethysmography
Secondly we will also determine the genotype of the AMPD1 gene We expect to find 15 subjects with the 34CT mutation which is a loss-of-function-mutation Cardiovascular patients with this mutation are known to have a survival benefit We will explore whether the post-occlusive reactive hyperemia in the forearm is potentiated because during ischaemia more adenosine is formed in these subjects
In 100 healthy young volunteers we will determine the genotype of the adenosine A2A receptor gene We expect to find approximately 15 subjects with the 1976TC polymorphisms It is known that this polymorphism is associated with an increased neuropsychological sensitivity to caffeine administration
We will explore whether this polymorphism is associated with a different vasodilating response to the administration of adenosine and caffeine into the brachial artery Blood flow will be measured with venous occlucion plethysmography
Secondly we will also determine the genotype of the AMPD1 gene We expect to find 15 subjects with the 34CT mutation which is a loss-of-function-mutation Cardiovascular patients with this mutation are known to have a survival benefit We will explore whether the post-occlusive reactive hyperemia in the forearm is potentiated because during ischaemia more adenosine is formed in these subjects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| ZonMw Nr 920-03-249 | None | None | None |