Ignite Creation Date:
2024-05-05 @ 12:08 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00258128
Status:
COMPLETED
Last Update Posted:
2019-04-30
First Post:
2005-11-22
Brief Title:
Effect of Salicylate on Glucose Metabolism in Insulin Resistance States
Sponsor:
Joslin Diabetes Center
Organization:
Joslin Diabetes Center
Study Overview
Official Title:
Effect of Salicylate on Glucose Metabolism in Insulin Resistance States
Status:
COMPLETED
Status Verified Date:
2019-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Data supports diet induced obesity leads to activation of the IKKNF-kB inflamatory pathway and that chronic inflammation leads to insulin resistance and diabetes In rodents salicylates inhibit IKKNF-kB and may improve insulin sensitivity We will study if this is true in people
Detailed Description:
Please see the following review articles on this topic
Shoelson SE Lee J Goldfine AB 2006 Inflammation in insulin resistance J Clin Invest 116 1793-1801
Goldfine AB Fonseca V and Shoelson SE 2010 Therapeutic approaches to target inflammation in type 2 diabetes Clin Chem 57 162-167
Donath MY and Shoelson SE 2011 Type 2 diabetes as an inflammatory disease Nat Rev Immunol 11 98-107
Goldfine AB and Shoelson SE 2017 Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk J Clin Invest 127 83-93
Shoelson SE Lee J Goldfine AB 2006 Inflammation in insulin resistance J Clin Invest 116 1793-1801
Goldfine AB Fonseca V and Shoelson SE 2010 Therapeutic approaches to target inflammation in type 2 diabetes Clin Chem 57 162-167
Donath MY and Shoelson SE 2011 Type 2 diabetes as an inflammatory disease Nat Rev Immunol 11 98-107
Goldfine AB and Shoelson SE 2017 Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk J Clin Invest 127 83-93
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DK051729 | NIH | None | httpsreporternihgovquickSearchR01DK051729 |
| R37DK051729 | NIH | None | None |