Ignite Creation Date:
2024-05-06 @ 9:35 AM
Last Modification Date:
2024-10-26 @ 12:17 PM
Study NCT ID:
NCT03028987
Status:
TERMINATED
Last Update Posted:
2017-09-12
First Post:
2017-01-19
Brief Title:
Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection SLVP031
Sponsor:
Stanford University
Organization:
Stanford University
Study Overview
Official Title:
Project 1 The Role of CD4 Memory Phenotype Memory and Effector T-Cells in Vaccination and Infection - Influenza-specific DR1501 and DR0701 T-cells
Status:
TERMINATED
Status Verified Date:
2017-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
LAIV was no longer recommended by ACIP
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is provide a better understanding of the adaptive immune response to the licensed flu vaccines The investigators hope the information learned from this study will help identify and describe important factors of influenza immunity especially of or specific proteins associated with the T-cell immune response
Detailed Description:
This is a study of up to 20 healthy monozygotic MZ twins 18-49 years old that are participants from past Stanford-LPCH Vaccine Program trials and who have been identified as human leukocyte antigen HLA DR1501 or DR0701 by lab assay results Volunteers will be contacted to assess interest in participating in this study Both twins in the pair must be willing to participate in the study All participants will be randomized within the twin pair to receive either the seasonal live attenuated influenza vaccine LAIV or the seasonal quadrivalent inactivated influenza vaccine IIV4 Immunization will be at Day 0 blood samples for immunogenicity assays will be collected prior to immunization and at Days 7 6-8 and 28 24-32
This study was halted due to the Advisory Committee on Immunization Practices decision not to recommend use of LAIV
This study was halted due to the Advisory Committee on Immunization Practices decision not to recommend use of LAIV
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2U19AI057229-11 | NIH | None | httpsreporternihgovquickSearch2U19AI057229-11 |