Ignite Creation Date:
2024-05-05 @ 12:08 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00254527
Status:
COMPLETED
Last Update Posted:
2007-05-02
First Post:
2005-11-14
Brief Title:
Colonization Infection and Molecular Typing of Methicillin-Resistant Staphylococcus Aureus MRSA in Children
Sponsor:
Childrens Mercy Hospital Kansas City
Organization:
Childrens Mercy Hospital Kansas City
Study Overview
Official Title:
Colonization Infection and Molecular Typing of Methicillin-Resistant Staphylococcus Aureus MRSA in Children
Status:
COMPLETED
Status Verified Date:
2005-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The intent of this study is to
1 Define the prevalence of MRSA carriage in the pediatric population in Kansas City
2 Systematically define patient risk factors for MRSA carriage and infection
3 Characterize the unique genetic characteristics of MRSA strains both community acquired CA and healthcare associated HCA that are present in the different pediatric populations
1 Define the prevalence of MRSA carriage in the pediatric population in Kansas City
2 Systematically define patient risk factors for MRSA carriage and infection
3 Characterize the unique genetic characteristics of MRSA strains both community acquired CA and healthcare associated HCA that are present in the different pediatric populations
Detailed Description:
Staphylococcus aureus SA are responsible for both localized and invasive infections including carbuncles cellulitis lymph node abscess and wound infections among others SA is a ubiquitous environmental organism that colonizes 30-50 adults and more than 50 of children with underlying skin disorders Hematogenous seeding can result in fulminant infection and sites as diverse as bone joint lung muscle pericardium endocardium and other vascular structures can be involved Factors which are known to increase the risk for colonization include the presence of underlying skin disorders and history of frequent needle use which occur in the setting of diabetes or hemodialysis Health care workers have traditionally been noted to have higher carriage rates
MRSA strains emerged in the last two decades in the US and similarities to the evolution of penicillin resistant S aureus were noted with colonization and infection in the hospital based setting noted first Again risk factors for MRSA colonization or infection in the hospital were noted to include prior antibiotic exposure admission to an intensive care unit surgery and exposure to an MRSA-colonized patient Emergence of CA-MRSA strains has been noted in the last decade having resistance to methicillin and erythromycin but susceptibility to clindamycin These strains have challenged the practitioners approach to the treatment of common skin and soft tissue infections as well as the management of invasive disease The importance of such strains was underscored by the 1999 report detailing the deaths of 4 US children with invasive MRSA infection none of whom had identifiable MRSA risk factors Pulsed field typing of the isolates confirmed that these community strains were distinct from nosocomial strains isolated from patients in local hospitals
This study seeks to more clearly define the prevalence of MRSA carriage better identify risk factors through personal interview and further identify resistance patterns and molecular strains This data will guide physicians at Childrens Mercy and in the community at large in choosing the best treatment option for children with MRSA infections
The absence of traditional risk factors for MRSA infection has been noted in children with CA infections Many studies that describe risk factors in MRSA patients do so by retrospective review of the medical record Misclassification of patients may occur as physicians do not routinely document the presence or absence of such risk factors particularly among household contacts
This study will look at nasal colonization for 500 children in the Kansas City area to determine prevalence of MRSA colonization During the study period all invasive MRSA isolates will also be collected Pulsed field typing will be done to determine whether the strains are community or healthcare associated and both groups will be compared
MRSA strains emerged in the last two decades in the US and similarities to the evolution of penicillin resistant S aureus were noted with colonization and infection in the hospital based setting noted first Again risk factors for MRSA colonization or infection in the hospital were noted to include prior antibiotic exposure admission to an intensive care unit surgery and exposure to an MRSA-colonized patient Emergence of CA-MRSA strains has been noted in the last decade having resistance to methicillin and erythromycin but susceptibility to clindamycin These strains have challenged the practitioners approach to the treatment of common skin and soft tissue infections as well as the management of invasive disease The importance of such strains was underscored by the 1999 report detailing the deaths of 4 US children with invasive MRSA infection none of whom had identifiable MRSA risk factors Pulsed field typing of the isolates confirmed that these community strains were distinct from nosocomial strains isolated from patients in local hospitals
This study seeks to more clearly define the prevalence of MRSA carriage better identify risk factors through personal interview and further identify resistance patterns and molecular strains This data will guide physicians at Childrens Mercy and in the community at large in choosing the best treatment option for children with MRSA infections
The absence of traditional risk factors for MRSA infection has been noted in children with CA infections Many studies that describe risk factors in MRSA patients do so by retrospective review of the medical record Misclassification of patients may occur as physicians do not routinely document the presence or absence of such risk factors particularly among household contacts
This study will look at nasal colonization for 500 children in the Kansas City area to determine prevalence of MRSA colonization During the study period all invasive MRSA isolates will also be collected Pulsed field typing will be done to determine whether the strains are community or healthcare associated and both groups will be compared
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None