Ignite Creation Date:
2024-05-06 @ 9:33 AM
Last Modification Date:
2024-10-26 @ 12:16 PM
Study NCT ID:
NCT03018262
Status:
COMPLETED
Last Update Posted:
2023-11-24
First Post:
2017-01-11
Brief Title:
Neurophysiology of Surround Inhibition in the Human Motor Cortex
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Detailed Evaluation of the Neurophysiology of Surround Inhibition in the Human Motor Cortex
Status:
COMPLETED
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
Movement disorders have many different causes and symptoms Researchers still do not fully understand which parts of the brain are involved in fine movement They want to learn about which brain regions could be abnormal in people with movement disorders
Objective
To better understand how the brain controls movement
Eligibility
Healthy right-handed adults age 18-70 years old
Design
Participants will be screened with a physical exam and questions about their handedness They may have a urine test
Participants will have 1 or 2 clinic visits The first visit will last about 15 hours The second will last about 3 hours
Participants will have structural magnetic resonance imaging MRI A strong magnetic field and radio waves take pictures of the brain Participants will lie on a table that slides in and out of a metal cylinder
Participants may have transcranial magnetic stimulation A wire coil is held on the scalp A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position
Participants will perform a simple index finger movement task
Participants may have surface electromyography from at least two hand muscles Small metal disk or adhesive pad electrodes will be taped to the skin Participants will be seated in a comfortable chair with their hands placed on a pillow
Participants may have an electroencephalography A cap with small disc electrodes will be placed on the scalp
Movement disorders have many different causes and symptoms Researchers still do not fully understand which parts of the brain are involved in fine movement They want to learn about which brain regions could be abnormal in people with movement disorders
Objective
To better understand how the brain controls movement
Eligibility
Healthy right-handed adults age 18-70 years old
Design
Participants will be screened with a physical exam and questions about their handedness They may have a urine test
Participants will have 1 or 2 clinic visits The first visit will last about 15 hours The second will last about 3 hours
Participants will have structural magnetic resonance imaging MRI A strong magnetic field and radio waves take pictures of the brain Participants will lie on a table that slides in and out of a metal cylinder
Participants may have transcranial magnetic stimulation A wire coil is held on the scalp A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position
Participants will perform a simple index finger movement task
Participants may have surface electromyography from at least two hand muscles Small metal disk or adhesive pad electrodes will be taped to the skin Participants will be seated in a comfortable chair with their hands placed on a pillow
Participants may have an electroencephalography A cap with small disc electrodes will be placed on the scalp
Detailed Description:
Objectives
The purpose of this protocol is to improve understanding of the neurophysiological mechanisms that underlie the phenomenon of surround inhibition in the human motor cortex It is known that patients with focal hand dystonia have abnormal motor surround inhibition However the physiology of this phenomenon still remains unclear The 3 sub-studies proposed under this protocol will integrate several neurophysiological techniques to explore different aspects of motor surround inhibition The objectives of sub-study 1 are a to identify the EEG correlate of motor SI b to determine the relationship between short interval intracortical inhibition SICI and SI both of which are compromised in patients with FHD and c to determine if there is an oscillatory frequency band that is relevant for SI The results from this sub-study will shed light on the inhibitory mechanisms that are critical for motor SI Sub-study 2 is aimed at determining the influence of parietal conditioning on motor surround inhibition If conditioning the parietal cortex enhances SI we can conclude that the parieto-motor inhibitory network may be involved in motor SI and that this network could be affected in focal hand dystonia Sub-study 3 will explore SI during different motor tasks
Study population
We intend to study up to 95 healthy volunteers in total Up to 30 participants will be recruited for sub-study 1 35 for sub-study 2 and 30 for sub-study 3
Design
Sub-study 1 This will be an exploratory study Participants will perform an auditory cued index finger movement task and motor evoked potentials will be elicited by stimulating the motor hotspot of a surround muscle using transcranial magnetic stimulation TMS EEG will be recorded continuously Single or paired TMS pulses with postero-anterior or antero-posterior current will be delivered either while the subject is at rest or at movement onset TMS-evoked potentials TEPs will be obtained by time-locked averaging of all the trials in each condition The amplitudes of the different peaks of the TEP will be compared across conditions which may be correlated with the degree of SI or SICI The components of the TEP that are most relevant to motor SI will thus be identified
Sub-study 2 This will be a hypothesis-driven study Our primary hypothesis is that parietal conditioning will influence motor SI in healthy volunteers Participants will perform an auditory cued index finger movement task and motor evoked potentials will be elicited by stimulating the motor hotspot of a surround muscle using transcranial magnetic stimulation Two coils one positioned over the motor cortex and the other over an inhibitory region of the inferior parietal lobule will deliver TMS pulses at a fixed inter-stimulus interval The pulses will be delivered either while the subject is at rest or at movement onset The ratio of mean MEP amplitude obtained with parietal conditioning to that obtained with motor cortex stimulation alone at movement onset will reveal any parieto-motor influence on SI
Sub-study 3 This will be an exploratory study Participants will be asked to perform different motor tasks such as activating an intrinsic hand muscle at different levels of activation sequential muscle activation or more complex tasks such as writing Single TMS pulses will be delivered at primary motor cortex at rest at the onset of the motor tasks or during the motor tasks MEPs will be measured in the active and surround muscles The ratios of MEP amplitudes during different levels of activation in the active and surround muscles will reveal
modulation of SI during these tasks
Outcome measures
For sub-study 1 our outcome measures will be 1 amplitudes of the different TEP peaks 2 degree of surround inhibition and short interval intracortical inhibition 3 correlation between them and relevant peak amplitudes 4 power and cortico-cortical coherence at different frequency bands
MEP amplitude will be the primary outcome measure in sub-study 2 and 3
The purpose of this protocol is to improve understanding of the neurophysiological mechanisms that underlie the phenomenon of surround inhibition in the human motor cortex It is known that patients with focal hand dystonia have abnormal motor surround inhibition However the physiology of this phenomenon still remains unclear The 3 sub-studies proposed under this protocol will integrate several neurophysiological techniques to explore different aspects of motor surround inhibition The objectives of sub-study 1 are a to identify the EEG correlate of motor SI b to determine the relationship between short interval intracortical inhibition SICI and SI both of which are compromised in patients with FHD and c to determine if there is an oscillatory frequency band that is relevant for SI The results from this sub-study will shed light on the inhibitory mechanisms that are critical for motor SI Sub-study 2 is aimed at determining the influence of parietal conditioning on motor surround inhibition If conditioning the parietal cortex enhances SI we can conclude that the parieto-motor inhibitory network may be involved in motor SI and that this network could be affected in focal hand dystonia Sub-study 3 will explore SI during different motor tasks
Study population
We intend to study up to 95 healthy volunteers in total Up to 30 participants will be recruited for sub-study 1 35 for sub-study 2 and 30 for sub-study 3
Design
Sub-study 1 This will be an exploratory study Participants will perform an auditory cued index finger movement task and motor evoked potentials will be elicited by stimulating the motor hotspot of a surround muscle using transcranial magnetic stimulation TMS EEG will be recorded continuously Single or paired TMS pulses with postero-anterior or antero-posterior current will be delivered either while the subject is at rest or at movement onset TMS-evoked potentials TEPs will be obtained by time-locked averaging of all the trials in each condition The amplitudes of the different peaks of the TEP will be compared across conditions which may be correlated with the degree of SI or SICI The components of the TEP that are most relevant to motor SI will thus be identified
Sub-study 2 This will be a hypothesis-driven study Our primary hypothesis is that parietal conditioning will influence motor SI in healthy volunteers Participants will perform an auditory cued index finger movement task and motor evoked potentials will be elicited by stimulating the motor hotspot of a surround muscle using transcranial magnetic stimulation Two coils one positioned over the motor cortex and the other over an inhibitory region of the inferior parietal lobule will deliver TMS pulses at a fixed inter-stimulus interval The pulses will be delivered either while the subject is at rest or at movement onset The ratio of mean MEP amplitude obtained with parietal conditioning to that obtained with motor cortex stimulation alone at movement onset will reveal any parieto-motor influence on SI
Sub-study 3 This will be an exploratory study Participants will be asked to perform different motor tasks such as activating an intrinsic hand muscle at different levels of activation sequential muscle activation or more complex tasks such as writing Single TMS pulses will be delivered at primary motor cortex at rest at the onset of the motor tasks or during the motor tasks MEPs will be measured in the active and surround muscles The ratios of MEP amplitudes during different levels of activation in the active and surround muscles will reveal
modulation of SI during these tasks
Outcome measures
For sub-study 1 our outcome measures will be 1 amplitudes of the different TEP peaks 2 degree of surround inhibition and short interval intracortical inhibition 3 correlation between them and relevant peak amplitudes 4 power and cortico-cortical coherence at different frequency bands
MEP amplitude will be the primary outcome measure in sub-study 2 and 3
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 17-N-0031 | None | None | None |