Ignite Creation Date:
2024-05-06 @ 9:32 AM
Last Modification Date:
2024-10-26 @ 12:16 PM
Study NCT ID:
NCT03008733
Status:
COMPLETED
Last Update Posted:
2022-05-06
First Post:
2016-11-09
Brief Title:
Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound 30-50MHZ in Demyelinating Neuropathies Inflammatory Demyelinating Polyneuropathy Chronic IPDC Neuropathy Multifocal Motor Block of Conducting NMMBC and Neuropathy With Antibody A MAG
Sponsor:
Centre Hospitalier Universitaire de Nice
Organization:
Centre Hospitalier Universitaire de Nice
Study Overview
Official Title:
Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound 30-50MHZ in Demyelinating Neuropathies Inflammatory Demyelinating Polyneuropathy Chronic IPDC Neuropathy Multifocal Motor Block of Conducting NMMBC and Neuropathy With Antibody A MAG
Status:
COMPLETED
Status Verified Date:
2022-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EchoNerf
Brief Summary:
The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a promising growing field 1 Non-invasive and painless ultrasound provides additional data electroneuromyography EMG with a spatial resolution at least as good as MRI while being easily accessible and inexpensiveThe polyradiculoneuritis Inflammatory Demyelinating Chronicles IPDC Neuropathies Motrices in Multifocal Conduction Blocks NMMBC and neuropathy associated with anti-MAG antibodies are among the major chronic inflammatory neuropathies with an autoimmune etiology The diagnosis of these pathologies is based on the clinic diagnostic tests and EMG The interest not only in the diagnosis but also for monitoring these pathologies using ultrasound analysis nerves has been demonstrated recently in several studies However the limited resolution of current ultrasound images do not allow detailed study of the internal structure of the nerves which could later help deepen knowledge in this innovative field and can better understand the pathophysiological mechanism of the evolution of these pathologies
To do this the investigators have available a UHF ultrasound in the ultrasound department of the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive analysis study pilot mono-centric multi and prospective on patients followed in the center with a diagnosis of IPDC a NMMBC or neuropathy with anti-MAG antibodies and control subjects matched by age and sex All the patients and controls in this study will receive a briefing and must sign an informed consent
They realize an ultrasound study of the nerve using an ultra high frequency ultrasound system that will allow the assessment of anatomical structures of nerve size structure vascularisation and assessment booklets Ultrasound data will in a second stage compared with the data obtained with the EMG and clinical scores obtained using clinical rating scales 40 subjects will be included divided into four subgroups 10 subjects with a diagnosis of IPDC 1 10 subjects with a diagnosis of NMMBC 2 10 subjects with a diagnosis of neuropathy antibody-anti MAG 3 and 10 control subjects with no signs of neuropathy at the EMG examination
To do this the investigators have available a UHF ultrasound in the ultrasound department of the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive analysis study pilot mono-centric multi and prospective on patients followed in the center with a diagnosis of IPDC a NMMBC or neuropathy with anti-MAG antibodies and control subjects matched by age and sex All the patients and controls in this study will receive a briefing and must sign an informed consent
They realize an ultrasound study of the nerve using an ultra high frequency ultrasound system that will allow the assessment of anatomical structures of nerve size structure vascularisation and assessment booklets Ultrasound data will in a second stage compared with the data obtained with the EMG and clinical scores obtained using clinical rating scales 40 subjects will be included divided into four subgroups 10 subjects with a diagnosis of IPDC 1 10 subjects with a diagnosis of NMMBC 2 10 subjects with a diagnosis of neuropathy antibody-anti MAG 3 and 10 control subjects with no signs of neuropathy at the EMG examination
Detailed Description:
The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a promising growing field 1 Non-invasive and painless ultrasound provides additional data electroneuromyography EMG with a spatial resolution at least as good as MRI while being easily accessible and inexpensiveThe polyradiculoneuritis Inflammatory Demyelinating Chronicles IPDC Neuropathies Motrices in Multifocal Conduction Blocks NMMBC and neuropathy associated with anti-MAG antibodies are among the major chronic inflammatory neuropathies with an autoimmune etiology The diagnosis of these pathologies is based on the clinic diagnostic tests and EMG The interest not only in the diagnosis but also for monitoring these pathologies using ultrasound analysis nerves has been demonstrated recently in several studies However the limited resolution of current ultrasound images do not allow detailed study of the internal structure of the nerves which could later help deepen knowledge in this innovative field and can better understand the pathophysiological mechanism of the evolution of these pathologies
To do this the investigators have available a UHF ultrasound in the ultrasound department of the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive analysis study pilot mono-centric multi and prospective on patients followed in the center with a diagnosis of IPDC a NMMBC or neuropathy with anti-MAG antibodies and control subjects matched by age and sex All the patients and controls in this study will receive a briefing and must sign an informed consent
They realize an ultrasound study of the nerve using an ultra high frequency ultrasound system that will allow the assessment of anatomical structures of nerve size structure vascularisation and assessment booklets Ultrasound data will in a second stage compared with the data obtained with the EMG and clinical scores obtained using clinical rating scales 40 subjects will be included divided into four subgroups 10 subjects with a diagnosis of IPDC 1 10 subjects with a diagnosis of NMMBC 2 10 subjects with a diagnosis of neuropathy antibody-anti MAG 3 and 10 control subjects with no signs of neuropathy at the EMG examination
The main objective of this pilot study is to provide a descriptive analysis of the morphology of the nerves with an ultra high frequency ultrasound in subgroups of CIDP patients anti-MAG antibodies and neuropathy NMMBC and controls The thickness of the epineurium the hallmarks of fascicular organization Doppler vascularity the nerve-sectional area the specification of the section surface nerve hypertrophy the thickness of the perineurium and ultrastructural characterization of the different fascicular organization typologies will be well analyzed in order to better understand the specific sonographic characteristics of each disease compared with controls no data exist at present in the literature with such image resolution
Secondary objectives
1 Compare the morphological characteristics obtained by ultra high frequency ultrasound between different subjects subgroups according to the morphological data collected and sonographic scores evaluation of nerve hypertrophy intra- and inter-ratio nerve nerve 4 and intra-fascicular nerve and nerve cross-ratio
2 To study the correlation between sonographic and clinical scores scores in different subjects subgroups using functional assessment scales MRC score R-ODS score INCAT ONLS ataxia Score and a torque rating of grip strength
3 To study the correlation between sonographic scores and electrophysiological scores by making a électroneurogramme ENG in the different subjects of subgroups the amplitude and distal motor latency for distal motor conduction the motor conduction velocities the presence of time dispersion or of a conduction block to the stepped motor conduction the latency of the waveform F to the proximal motor conduction and the amplitude of the sensory potential for sensory conduction
To do this the investigators have available a UHF ultrasound in the ultrasound department of the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive analysis study pilot mono-centric multi and prospective on patients followed in the center with a diagnosis of IPDC a NMMBC or neuropathy with anti-MAG antibodies and control subjects matched by age and sex All the patients and controls in this study will receive a briefing and must sign an informed consent
They realize an ultrasound study of the nerve using an ultra high frequency ultrasound system that will allow the assessment of anatomical structures of nerve size structure vascularisation and assessment booklets Ultrasound data will in a second stage compared with the data obtained with the EMG and clinical scores obtained using clinical rating scales 40 subjects will be included divided into four subgroups 10 subjects with a diagnosis of IPDC 1 10 subjects with a diagnosis of NMMBC 2 10 subjects with a diagnosis of neuropathy antibody-anti MAG 3 and 10 control subjects with no signs of neuropathy at the EMG examination
The main objective of this pilot study is to provide a descriptive analysis of the morphology of the nerves with an ultra high frequency ultrasound in subgroups of CIDP patients anti-MAG antibodies and neuropathy NMMBC and controls The thickness of the epineurium the hallmarks of fascicular organization Doppler vascularity the nerve-sectional area the specification of the section surface nerve hypertrophy the thickness of the perineurium and ultrastructural characterization of the different fascicular organization typologies will be well analyzed in order to better understand the specific sonographic characteristics of each disease compared with controls no data exist at present in the literature with such image resolution
Secondary objectives
1 Compare the morphological characteristics obtained by ultra high frequency ultrasound between different subjects subgroups according to the morphological data collected and sonographic scores evaluation of nerve hypertrophy intra- and inter-ratio nerve nerve 4 and intra-fascicular nerve and nerve cross-ratio
2 To study the correlation between sonographic and clinical scores scores in different subjects subgroups using functional assessment scales MRC score R-ODS score INCAT ONLS ataxia Score and a torque rating of grip strength
3 To study the correlation between sonographic scores and electrophysiological scores by making a électroneurogramme ENG in the different subjects of subgroups the amplitude and distal motor latency for distal motor conduction the motor conduction velocities the presence of time dispersion or of a conduction block to the stepped motor conduction the latency of the waveform F to the proximal motor conduction and the amplitude of the sensory potential for sensory conduction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None