Ignite Creation Date:
2024-05-06 @ 9:30 AM
Last Modification Date:
2024-10-26 @ 12:15 PM
Study NCT ID:
NCT02997319
Status:
COMPLETED
Last Update Posted:
2021-05-19
First Post:
2016-12-13
Brief Title:
Shift Work Heredity Insulin and Food Timing Study
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Shift Work Heredity Insulin and Food Timing SHIFT Study
Status:
COMPLETED
Status Verified Date:
2021-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SHIFT
Brief Summary:
The purpose of this study is to determine whether night time eating that coincides with elevated endogenous melatonin impairs glucose tolerance particularly in carriers of the MTNR1B risk allele
Detailed Description:
Preliminary observations suggest that food intake coincident with high melatonin levels leads to impaired glucose tolerance-particularly in MTNR1B risk allele carriers Our objectives are to determine the effect of concurrent food intake and melatonin on glucose tolerance and to assess the role of MTNR1B single nucleotide polymorphism SNPmelatonin interaction in this deleterious effect Our central hypothesis is that concurrent high melatonin levels and food intake commonly experienced in night shift workers cause long-term impairment of glucose tolerance and that this effect is worse in carriers of the MTNR1B type 2 diabetes T2D risk SNP than in non-carriers The results of this proposal will help to clarify an ongoing controversy about the role of melatonin in glucose tolerance and will help to develop novel strategies in the prevention and treatment of T2D especially in shift workers night eaters and MTNR1B risk allele carriers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DK105072 | NIH | None | httpsreporternihgovquickSearchR01DK105072 |