Ignite Creation Date:
2024-05-06 @ 9:25 AM
Last Modification Date:
2024-10-26 @ 12:14 PM
Study NCT ID:
NCT02974192
Status:
UNKNOWN
Last Update Posted:
2017-01-18
First Post:
2016-11-23
Brief Title:
Neopterin Effects on Ischemic Stroke
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Neoptrin Soluble CD40-ligand and Ischemic Stroke a Clinical Perspective
Status:
UNKNOWN
Status Verified Date:
2017-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Ischemic stroke accounts for the majority of stroke cases and constitutes a major cause of death and disability in industrial world Inflammation has been reported to constitute a major component of ischemic stroke pathology The brain responds to ischemic injury with an acute andprolonged inflammatory process Few studies have investigated the relationship between acute biomarkers of inflammation and functional outcome following stroke
Detailed Description:
This case -control observational prospective study will be conducted on 100 patients with first -ever acute onset ischemic stroke within 24-48 hours Their ages ranged-years old mean age years All participants will be subjected to thorough history taking full clinical and neurological examination Complete neurological examination where the following clinical and demographical data will be taken age sex stroke etiology presence of stroke risk factors as smoking history hyperlipidemia diabetes mellitus history of hypertension history of transient ischemic attacks history of myocardial infarction or any cardiac problems Stroke subtype will be classified according to the criteria of Trial of Org 10172 in acute Stroke Treatment TOAST classification The clinical stroke syndrome will be determined by applying the criteria of the Oxfordshire Community Stroke project OCSP Stroke severity will be assessed by Scandinavian Stroke Scale SSS and Modified Rankin Scale mRS will be measured at the time of admission Brain imaging either CT scan and or MRI will be performed after admission Electrocardiography ECG Echocardiography ECHO Carotid and vertibrobasilar Duplex will be done for all patients Blood samples will be drawn for assessment of complete blood picture CBC Random blood glucose levels renal function tests RFT liver function tests LFT thyroid function tests TFT Lipid profile Soluble CD40 Ligand and Neopetrin by using standard laboratory methods on the first day of admission
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None