Ignite Creation Date:
2024-05-05 @ 12:07 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00246493
Status:
TERMINATED
Last Update Posted:
2019-12-09
First Post:
2005-10-27
Brief Title:
Vascular Aging The Link That Bridges Age to Atherosclerosis The VALIDATE Study
Sponsor:
National Institute on Aging NIA
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Vascular Aging The Link That Bridges Age to Atherosclerosis The VALIDATE Study
Status:
TERMINATED
Status Verified Date:
2017-11-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The prevalence incidence and severity of atherosclerotic disease all markedly increase with age Basic experimental and observational data demonstrate that aging magnifies the pathologic and clinical consequences of established risk factors and is the most potent individual risk factor for coronary atherosclerosis and for adverse outcomes following an ischemic event These findings suggest that normal aging alters the vascular substrate so as to promote the development and progression of atherosclerosis The age-associated changes in vascular structure and function include an increase in central vascular stiffness intimal proliferation and endothelial dysfunction The major hypothesis is that the above alterations in vascular substrate ie vascular age are an important determinant of the age associated increased likelihood for the development and progression of coronary atherosclerotic disease
This program will non-invasively characterize vascular age and atherosclerotic burden in BLSA participants and individuals with successful aging ie those with no or minimal evidence of coronary atherosclerotic disease and those with premature clinically evident coronary artery disease It will repeat measures of vascular age and atherosclerotic burden three years after the first assessment By examining the impact of vascular age on the initial extent and the progression of atherosclerotic burden over a two to three-year period it will test the hypothesis that vascular age is an important determinant of the ageassociated increase in atherosclerotic disease
This program will non-invasively characterize vascular age and atherosclerotic burden in BLSA participants and individuals with successful aging ie those with no or minimal evidence of coronary atherosclerotic disease and those with premature clinically evident coronary artery disease It will repeat measures of vascular age and atherosclerotic burden three years after the first assessment By examining the impact of vascular age on the initial extent and the progression of atherosclerotic burden over a two to three-year period it will test the hypothesis that vascular age is an important determinant of the ageassociated increase in atherosclerotic disease
Detailed Description:
The prevalence incidence and severity of atherosclerotic disease all markedly increase with age Basic experimental and observational data demonstrate that aging magnifies the pathologic and clinical consequences of established risk factors and is the most potent individual risk factor for coronary atherosclerosis and for adverse outcomes following an ischemic event These findings suggest that normal aging alters the vascular substrate so as to promote the development and progression of atherosclerosis The age-associated changes in vascular structure and function include an increase in central vascular stiffness intimal proliferation and endothelial dysfunction The major hypothesis is that the above alterations in vascular substrate ie vascular age are an important determinant of the age associated increased likelihood for the development and progression of coronary atherosclerotic disease
This protocol will non-invasively characterize vascular age and atherosclerotic burden in BLSA participants and individuals with successful aging ie those with no or minimal evidence of coronary atherosclerotic disease and those with premature clinically evident coronary artery disease It will repeat measures of vascular age and atherosclerotic burden three years after the first assessment By examining the impact of vascular age on the initial extent and the progression of atherosclerotic burden over a two to three-year period it will test the hypothesis that vascular age is an important determinant of the age-associated increase in atherosclerotic disease
This protocol will non-invasively characterize vascular age and atherosclerotic burden in BLSA participants and individuals with successful aging ie those with no or minimal evidence of coronary atherosclerotic disease and those with premature clinically evident coronary artery disease It will repeat measures of vascular age and atherosclerotic burden three years after the first assessment By examining the impact of vascular age on the initial extent and the progression of atherosclerotic burden over a two to three-year period it will test the hypothesis that vascular age is an important determinant of the age-associated increase in atherosclerotic disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-AG-N294 | None | None | None |