Ignite Creation Date:
2024-05-06 @ 9:22 AM
Last Modification Date:
2024-10-26 @ 12:13 PM
Study NCT ID:
NCT02961127
Status:
UNKNOWN
Last Update Posted:
2016-11-10
First Post:
2016-11-06
Brief Title:
Association Study to Evaluate TFPI Gene in CAD in Han Chinese
Sponsor:
Chinese PLA General Hospital
Organization:
Chinese PLA General Hospital
Study Overview
Official Title:
Association Study to Evaluate TFPI Gene in CAD in Han Chinese
Status:
UNKNOWN
Status Verified Date:
2016-11
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The cases were hospitalized patients from two medical centers in Beijing and Harbin respectively Venous blood was collected by standard vein puncture in fasting condition
Detailed Description:
In our study the CAD was defined by one of the following criteria 1 based on World Health Organization criteria in terms of elevations of cardiac enzymes electrocardiography ECG and clinical symptoms angina chest pressure or shortness of breath 2 angiographic evidence of more than 50 stenosis in one or more major coronary arteries 3 previous history of PCI percutaneous coronary intervention or CABG coronary artery bypass graft The controls were selected from the two medical centers meeting the following criteria 1 with no family history for CAD 2 no clinical symptoms for CAD 3 resting ECG showed normal results The subjects with two or more risk factors of CAD age45 for man and 55 for woman hypertension diabetes overweight hyperlipidemia were subjected to treadmill stress test and selected as controls if their ECG were normal without clinical symptoms Those with history of cardiomyopathy valvular disease peripheral vascular disease stroke severe hepatic and kidney deficiency were excluded in our study
Venous blood was collected by standard vein puncture in fasting condition Four single-nucleotide polymorphisms SNPs rs7586970 rs6434222 rs10153820 and rs8176528 were detected with polymerase chain reaction-direct sequencing method And the genotypes of these SNPs were determined in both CAD patients and non-CAD controls
Venous blood was collected by standard vein puncture in fasting condition Four single-nucleotide polymorphisms SNPs rs7586970 rs6434222 rs10153820 and rs8176528 were detected with polymerase chain reaction-direct sequencing method And the genotypes of these SNPs were determined in both CAD patients and non-CAD controls
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None