Ignite Creation Date:
2024-05-06 @ 9:21 AM
Last Modification Date:
2024-10-26 @ 12:13 PM
Study NCT ID:
NCT02961829
Status:
COMPLETED
Last Update Posted:
2020-07-28
First Post:
2015-12-18
Brief Title:
Multi Interventional Study Exploring HIV-1 Residual Replication a Step Towards HIV-1 Eradication and Sterilizing Cure
Sponsor:
Federal University of São Paulo
Organization:
Federal University of São Paulo
Study Overview
Official Title:
Multi Interventional Study Exploring HIV-1 Residual Replication a Step Towards HIV-1 Eradication and Sterilizing Cure
Status:
COMPLETED
Status Verified Date:
2020-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It is becoming clear that a combination of interventions will be desirable to achieve HIV cure Therefore the investigators propose a pilot proof of concept study using combination of a number of different interventions for eradicating residual plasma viremia and decreasing HIV reservoirs The investigators hypothesize that i antiretroviral intensification using Maraviroc andor dolutegravir with ii Dendritic Cell vaccination using autologous HIV and iii purging intervention using the Class III HDACs Sirtuin-1 and iv decreasing the ratio of long-lived central memory TCMtransitional memory TTM CD4 T-cells using Auranofin will provide a synergistic impact leading to a sterilizing cure of HIV infection Results of this study may provide insightful evidence for planning the next steps using the more efficacious combination of intervention strategies towards HIV sterilizing cure
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None