Ignite Creation Date:
2024-05-06 @ 9:21 AM
Last Modification Date:
2024-10-26 @ 12:13 PM
Study NCT ID:
NCT02965339
Status:
UNKNOWN
Last Update Posted:
2018-05-01
First Post:
2016-11-14
Brief Title:
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Sponsor:
Centre Hospitalier Universitaire Amiens
Organization:
Centre Hospitalier Universitaire Amiens
Study Overview
Official Title:
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Status:
UNKNOWN
Status Verified Date:
2018-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DYVA
Brief Summary:
Cardiac surgery patients have many risk factors for endothelial dysfunction hypertension atherosclerosis dyslipidemia chronic renal failure
It is likely that a significant number of patients suffering from a preexisting endothelial dysfunction This endothelial dysfunction can be assessed by a molecular approach determination of NO ICAM1 VCAM1 IL8 endothelial microparticles Extracorporeal circulation with ischemia-reperfusion causes a breach of particularly important glycocalyx as ischemia-reperfusion injury is No studies have evaluated the time course of the infringement and its association with the immediate post-operative complications SIRS coagulopathy vasoplegic syndrome renal failure Only one study has regained an association between endothelial dysfunction during cardiac bypass surgery and postoperative cardiac surgery vasoplegic syndrome A study in noncardiac surgery has regained an association between endothelial dysfunction assessed by a vasoplegia test and postoperative acute renal failure Thus there is some data in the literature to suggest that the occurrence of postoperative complications SIRS coagulopathy capillary leak syndrome acute circulatory failure vasoplegic and acute renal failure may result from the interaction between a pre-existing endothelial dysfunction and operative aggression extracorporeal circulation The onset of complications result from an interaction that depends on the importance of endothelial dysfunction at baseline
It is likely that a significant number of patients suffering from a preexisting endothelial dysfunction This endothelial dysfunction can be assessed by a molecular approach determination of NO ICAM1 VCAM1 IL8 endothelial microparticles Extracorporeal circulation with ischemia-reperfusion causes a breach of particularly important glycocalyx as ischemia-reperfusion injury is No studies have evaluated the time course of the infringement and its association with the immediate post-operative complications SIRS coagulopathy vasoplegic syndrome renal failure Only one study has regained an association between endothelial dysfunction during cardiac bypass surgery and postoperative cardiac surgery vasoplegic syndrome A study in noncardiac surgery has regained an association between endothelial dysfunction assessed by a vasoplegia test and postoperative acute renal failure Thus there is some data in the literature to suggest that the occurrence of postoperative complications SIRS coagulopathy capillary leak syndrome acute circulatory failure vasoplegic and acute renal failure may result from the interaction between a pre-existing endothelial dysfunction and operative aggression extracorporeal circulation The onset of complications result from an interaction that depends on the importance of endothelial dysfunction at baseline
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None