Ignite Creation Date:
2024-05-05 @ 12:06 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00247637
Status:
COMPLETED
Last Update Posted:
2013-07-03
First Post:
2005-10-31
Brief Title:
The Genetic Basis of Inherited Neurologic Deficits in People With Schizophrenia
Sponsor:
University of California San Diego
Organization:
University of California San Diego
Study Overview
Official Title:
The Genetics of Endophenotypes and Schizophrenia
Status:
COMPLETED
Status Verified Date:
2013-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a study of the genetic basis of brain dysfunction in people with schizophrenia
Detailed Description:
Schizophrenia is a disabling disorder that is associated with specific inheritable neurobiologic deficits These deficits can cause problems with memory visual attention information processing and other aspects of daily living Understanding the genetic components of these deficits in people with schizophrenia and their unaffected family members may help uncover the neurobiological basis risk factors and heritability of the disease In addition the information may serve to create more effective treatments and possibly a cure for the disease This study will serve to provide information about the genetic basis of known inherited neurobiological deficits in people with schizophrenia In turn this may guide further studies on the genetics of schizophrenia
Participants will attend 2 study visits each of which will last approximately 4 hours The first will include blood tests and diagnostic interviews of participating families to evaluate the presence of schizophrenic symptoms The second study visit will entail four neurocognitive and neurophysiological tests Participants will first have a pre-pulse inhibition test which uses electrodes to measure eye blinking Electrodes will also be placed on participants head ears and around their eyes to measure brain waves Next participants will undergo an oculomotor test during which they will wear glasses fitted with sensors that record eye movement Participants will then be asked to repeat a list of words letters and numbers read by a researcher Last participants will undergo a computerized performance test requiring them to watch the computer screen and click a mouse whenever they see a number between 0 and 9 Each study visit will take approximately 4 hours
Participants will attend 2 study visits each of which will last approximately 4 hours The first will include blood tests and diagnostic interviews of participating families to evaluate the presence of schizophrenic symptoms The second study visit will entail four neurocognitive and neurophysiological tests Participants will first have a pre-pulse inhibition test which uses electrodes to measure eye blinking Electrodes will also be placed on participants head ears and around their eyes to measure brain waves Next participants will undergo an oculomotor test during which they will wear glasses fitted with sensors that record eye movement Participants will then be asked to repeat a list of words letters and numbers read by a researcher Last participants will undergo a computerized performance test requiring them to watch the computer screen and click a mouse whenever they see a number between 0 and 9 Each study visit will take approximately 4 hours
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DNBBS 7G-GRR | US NIH GrantContract | None | httpsreporternihgovquickSearchR01MH065562 |
| R01MH065571 | NIH | None | None |
| R01MH065707 | NIH | None | None |
| R01MH065578 | NIH | None | None |
| R01MH065588 | NIH | None | None |
| R01MH065554 | NIH | None | None |
| R01MH065562 | NIH | None | None |