Ignite Creation Date:
2024-05-06 @ 9:15 AM
Last Modification Date:
2024-10-26 @ 12:11 PM
Study NCT ID:
NCT02933424
Status:
COMPLETED
Last Update Posted:
2018-01-25
First Post:
2016-09-27
Brief Title:
Project Plant Protein the P3 Study in Humans
Sponsor:
Clinical Nutrition Research Centre Singapore
Organization:
Clinical Nutrition Research Centre Singapore
Study Overview
Official Title:
The Effects of Plant Proteins on Blood Glucose Amino Acid Levels and Satiety in Humans
Status:
COMPLETED
Status Verified Date:
2018-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this study is to compare the effects of adding three plant-based proteins rice oats and pea proteins to a breakfast beverage on the glycemic response appetite and subsequent food intake of healthy adults
Detailed Description:
A diet or a meal higher in dietary protein has been reported to promote satiety and suppress food intake in humans in several previous studies It was suggested that the presence of amino acid in the blood as a result of higher protein intake served as signals that suppress appetite in humans More recently it has been observed that incomplete or lower quality proteins ie those missing one or more essential amino acids may suppress hunger more than complete proteins as the ingestion of incomplete proteins in the long term may lead to deficiency of essential amino acids Plant proteins are generally considered incomplete protein when compared to animal proteins which mean that plant protein may have higher appetite-suppressing effects
Dietary carbohydrates are the most potent stimuli of insulin secretion However the addition of dietary protein in a carbohydrate-rich meal has been shown to further stimulate insulin releaseThe insulinotropic effect of dietary protein is thought to be attributed to the branched-chain amino acid BCAA content of the protein-rich meal Interestingly there is a hierarchy of effects induced by protein from different sources For example milk protein has been shown to be superior to fish or plant protein in stimulating insulin secretion following a mealEven within milk protein whey protein stimulated insulin secretion more than casein protein One of the factors that distinguish whey from casein proteins was the digestibility or the digestion rate of these proteins Protein that is digested faster appear to increase blood amino acid levels faster and increase insulin release fasterThis implies that plant proteins that have lower digestibility rate relative to animal proteins may have lower insulinotropic effects and the effective dose required to achieve optimal insulin secretion may be different from animal protein and warrants further investigation In addition the amino acid profile in addition to lower digestibility of plant proteins may differ from animal protein especially the BCAA content that is associated with the stimulation of insulin secretion
Dietary patterns and cuisines vary between countries and cultures Unlike in the Western countries plant-based foods are more commonly consumed in an Asian cuisine Based on the statistics released by Food and Agriculture Organization cereals and meat are the top two protein sources in both Western 291 and 264 respectively and Asian 588 and 86 respectively countries The third major source of protein is dairy 167 in Western countries and pulses in Asia 74 In addition vegetarianism is widely practiced in Asian countries Studies investigating the appetitive and the blood glucose regulating effects of dietary protein have been focused predominantly in animal protein with a number of studies included plant-based protein such as soy protein Since cereals and pulses are an important part of an Asian cuisine it is important to understand and compare the effects of proteins from these sources on blood glucose and appetite regulation Since the amino acid profile and the digestibility of these plant-based proteins differ from animal protein it is important to also understand the effective dose that exerts optimal effects
Dietary carbohydrates are the most potent stimuli of insulin secretion However the addition of dietary protein in a carbohydrate-rich meal has been shown to further stimulate insulin releaseThe insulinotropic effect of dietary protein is thought to be attributed to the branched-chain amino acid BCAA content of the protein-rich meal Interestingly there is a hierarchy of effects induced by protein from different sources For example milk protein has been shown to be superior to fish or plant protein in stimulating insulin secretion following a mealEven within milk protein whey protein stimulated insulin secretion more than casein protein One of the factors that distinguish whey from casein proteins was the digestibility or the digestion rate of these proteins Protein that is digested faster appear to increase blood amino acid levels faster and increase insulin release fasterThis implies that plant proteins that have lower digestibility rate relative to animal proteins may have lower insulinotropic effects and the effective dose required to achieve optimal insulin secretion may be different from animal protein and warrants further investigation In addition the amino acid profile in addition to lower digestibility of plant proteins may differ from animal protein especially the BCAA content that is associated with the stimulation of insulin secretion
Dietary patterns and cuisines vary between countries and cultures Unlike in the Western countries plant-based foods are more commonly consumed in an Asian cuisine Based on the statistics released by Food and Agriculture Organization cereals and meat are the top two protein sources in both Western 291 and 264 respectively and Asian 588 and 86 respectively countries The third major source of protein is dairy 167 in Western countries and pulses in Asia 74 In addition vegetarianism is widely practiced in Asian countries Studies investigating the appetitive and the blood glucose regulating effects of dietary protein have been focused predominantly in animal protein with a number of studies included plant-based protein such as soy protein Since cereals and pulses are an important part of an Asian cuisine it is important to understand and compare the effects of proteins from these sources on blood glucose and appetite regulation Since the amino acid profile and the digestibility of these plant-based proteins differ from animal protein it is important to also understand the effective dose that exerts optimal effects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None