Ignite Creation Date:
2024-05-06 @ 9:14 AM
Last Modification Date:
2024-10-26 @ 12:12 PM
Study NCT ID:
NCT02939781
Status:
TERMINATED
Last Update Posted:
2021-06-25
First Post:
2016-10-11
Brief Title:
Measuring the Metabolic Cost of Fever
Sponsor:
Great Ormond Street Hospital for Children NHS Foundation Trust
Organization:
Great Ormond Street Hospital for Children NHS Foundation Trust
Study Overview
Official Title:
Measuring Energy Expenditure Before and After Fever in Critically Ill Children
Status:
TERMINATED
Status Verified Date:
2016-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Unable to recruit to protocol
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IGUANA
Brief Summary:
Fever is part of the bodys immune response often triggered by infection Fever is commonly treated with medicines such as paracetamol mainly because people feel unwell with fever However fever does have a role in fighting infection it enables the rest of the immune system to function more efficiently and may directly stop bacteria and viruses from multiplying In most cases however treating fever does not matter because the rest of the immune system can cope well enough to fight the infection with or without additional treatment like antibiotics
In critically ill patients however any advantage in the fight against infection may be crucial In a large observational study of adult patients in the intensive care unit patients who developed an early fever with temperature between 385-395 degrees C fared relatively better than patients who were colder So it is possible that in critical illness fever may be beneficial However in critical illness the body does have limited energy resources In order to raise the body temperature energy is required However the investigators do not know how much energy is required to generate a fever in critically ill children This study will aim to try and measure the energy required to generate a fever in a critically ill child The investigators will measure energy expenditure directly in children admitted to the intensive care unit by measuring the levels of oxygen and carbon dioxide they breathe in and out a method called indirect calorimetry This will enable the investigators to judge whether the benefits of a fever can be justified by the energy costs in the energy depleted state that is critical illness
In critically ill patients however any advantage in the fight against infection may be crucial In a large observational study of adult patients in the intensive care unit patients who developed an early fever with temperature between 385-395 degrees C fared relatively better than patients who were colder So it is possible that in critical illness fever may be beneficial However in critical illness the body does have limited energy resources In order to raise the body temperature energy is required However the investigators do not know how much energy is required to generate a fever in critically ill children This study will aim to try and measure the energy required to generate a fever in a critically ill child The investigators will measure energy expenditure directly in children admitted to the intensive care unit by measuring the levels of oxygen and carbon dioxide they breathe in and out a method called indirect calorimetry This will enable the investigators to judge whether the benefits of a fever can be justified by the energy costs in the energy depleted state that is critical illness
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None