Ignite Creation Date:
2024-05-06 @ 9:12 AM
Last Modification Date:
2024-10-26 @ 12:11 PM
Study NCT ID:
NCT02925923
Status:
COMPLETED
Last Update Posted:
2020-05-04
First Post:
2016-09-27
Brief Title:
Crushed Ticagrelor Versus Eptifibatide Bolus Clopidogrel
Sponsor:
University of Alabama at Birmingham
Organization:
University of Alabama at Birmingham
Study Overview
Official Title:
The Effects of Crushed Ticagrelor Versus Eptifibatide Bolus Clopidogrel in Troponin-Negative ACS Patients Undergoing Coronary Intervention
Status:
COMPLETED
Status Verified Date:
2020-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with troponin-negative acute coronary syndrome ACS are not routinely pre-treated with P2Y12 inhibitors and the rate of high on-treatment platelet reactivity HPR remains elevated after a loading dose of ticagrelor at the time of percutaneous coronary intervention PCI This suggests that faster platelet inhibition with crushed ticagrelor eptifibatide or cangrelor is needed to reduce HPR and periprocedural myocardial infarction and injury PMI The present study compared the effects of crushed ticagrelor vs eptifibatide bolus clopidogrel in troponin-negative ACS patients undergoing PCI
Detailed Description:
Platelet activation and accumulation causes the formation of blood clots that may cause heart attack As a standard of care the doctor can prescribe medications such as are ticagrelor eptifibatide clopidogrel to prevent the formation of blood clots
100 patients with unstable angina both male and female will be randomized to either Group A- Crushed Ticagrelor or Group B- Eptifibatide bolus Clopidogrel administrated immediately before PCI Platelet function testing troponin and ECG will be performed
100 patients with unstable angina both male and female will be randomized to either Group A- Crushed Ticagrelor or Group B- Eptifibatide bolus Clopidogrel administrated immediately before PCI Platelet function testing troponin and ECG will be performed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None