Ignite Creation Date:
2024-05-05 @ 12:06 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00242021
Status:
COMPLETED
Last Update Posted:
2022-12-16
First Post:
2005-10-18
Brief Title:
The Effect of Fatty Acid Composition on Energy Intake and Satiety
Sponsor:
TNO
Organization:
TNO
Study Overview
Official Title:
Fatty Acid Composition of a Fat Supplement on Energy Intake Satiety and Fat Metabolism in Lean and Obese Men
Status:
COMPLETED
Status Verified Date:
2022-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of the study is to investigate the effect of fatty acid composition of a fat supplement
1 acutely after single intake on subjective and objective measurements of hunger satiety and wellness on energy intake and postprandial hormonal changes
2 in the long-term after one week on regulators of fat tissue metabolism
1 acutely after single intake on subjective and objective measurements of hunger satiety and wellness on energy intake and postprandial hormonal changes
2 in the long-term after one week on regulators of fat tissue metabolism
Detailed Description:
One of the physiological factors regulating the food intake pattern is satiety Satiety is defined as the absence of ingestive motivation which ends when the next meal is initiated Blundell et al 1996 Food intake affects a number of physiological objective parameters in blood known to be involved in signaling satiety such as glucose Melanson et al 1999 Chapman et al 1999 Campfield et al 1996 insulin Speechly et al 2000 and cholecystokinin CCK Gutzwiller et al 2000 Beglinger et al 2001 French et al 2000 Degen et al 2001 Burton-Freemanet al 2002 2004 More recently the gastric hormone ghrelin was identified as a marker for hunger and meal initiation De Graaf et al 2004 Ghrelin concentrations in blood were highly correlated with subjective measures of appetite PYY a gut hormone produced postprandially will be measured in this study because it has been mentioned that this hormone inhibits food intake Batterham et al 2003 The baseline level of PYY is lower in obese subjects than in lean subjects The two groups different in body weight will therefore show different baseline levels and perhaps different curves as well
Humans do not only eat in response to a metabolic or physiological need Humans also respond to a significant extend to other internal subjective and emotional signals cues The exact relations between the physiological internal signals and subjective and emotional internal signals are not known Besides also external and social factors modulate physiological-derived hunger and satiety signals
In the present clinical trial the effect of fatty acid composition of a fat supplement will be studied on hunger and satiety In the supplement a mixture of fatty acids known for their satiating effect will be tested and will be compared with a control supplement containing fatty acids normally consumed with breakfast
Humans do not only eat in response to a metabolic or physiological need Humans also respond to a significant extend to other internal subjective and emotional signals cues The exact relations between the physiological internal signals and subjective and emotional internal signals are not known Besides also external and social factors modulate physiological-derived hunger and satiety signals
In the present clinical trial the effect of fatty acid composition of a fat supplement will be studied on hunger and satiety In the supplement a mixture of fatty acids known for their satiating effect will be tested and will be compared with a control supplement containing fatty acids normally consumed with breakfast
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None