Ignite Creation Date:
2024-05-06 @ 9:06 AM
Last Modification Date:
2024-10-26 @ 12:10 PM
Study NCT ID:
NCT02909244
Status:
COMPLETED
Last Update Posted:
2017-08-25
First Post:
2016-09-05
Brief Title:
Study of Gut Microbiota in Primary Immune Deficiency Possibly Associated With Inflammatory Bowel Disease
Sponsor:
Imagine Institute
Organization:
Imagine Institute
Study Overview
Official Title:
Study of Gut Microbiota in Primary Immune Deficiencies Possibly Associated With Inflammatory Bowel Disease Chronic Granulomatous Disease XIAP Gene Deficiency or TTC7A Gene Deficiency
Status:
COMPLETED
Status Verified Date:
2017-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DIPobiota
Brief Summary:
Some Primary Immune Deficiencies can be associated with an inflammatory bowel disease mimicking Crohn disease the Chronic Granulomatous Disease CGD the XIAP deficiency and the TTC7A deficiency
This inflammatory bowel disease is frequent but inconstant raising questions about other factors contributing to the disease The aim of our study is to analyze describe and compare the gut microbiota of patients with those primary immune deficiency with or without intestinal disease
The investigators can expect in the long term to compare on a same patient the gut microbiota evolution and to assess the role of gut microbiota modifications on the onset of an inflammatory bowel disease
This inflammatory bowel disease is frequent but inconstant raising questions about other factors contributing to the disease The aim of our study is to analyze describe and compare the gut microbiota of patients with those primary immune deficiency with or without intestinal disease
The investigators can expect in the long term to compare on a same patient the gut microbiota evolution and to assess the role of gut microbiota modifications on the onset of an inflammatory bowel disease
Detailed Description:
The investigators will include patients adults or children with Primary Immune Deficiency CGD XIAP or TTC7A deficiencies and they will collect feces samples from them
In parallel as control groups patients with no inflammatory bowel disease and no primary immune deficiency will be included and also patients suffering from Crohns disease without known primary immune deficiency
The laboratory collaborators will then realize analyzes on the microbiota collected for all patients
The study team will then analyze the microbiota composition of the different types of patients and try to identify some factors associated with the appearance of an inflammatory disease on these patients
In parallel as control groups patients with no inflammatory bowel disease and no primary immune deficiency will be included and also patients suffering from Crohns disease without known primary immune deficiency
The laboratory collaborators will then realize analyzes on the microbiota collected for all patients
The study team will then analyze the microbiota composition of the different types of patients and try to identify some factors associated with the appearance of an inflammatory disease on these patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None