Ignite Creation Date:
2024-05-06 @ 9:06 AM
Last Modification Date:
2024-10-26 @ 12:10 PM
Study NCT ID:
NCT02906436
Status:
COMPLETED
Last Update Posted:
2017-04-20
First Post:
2016-09-11
Brief Title:
Ex-Vivo Lung Reconditioning
Sponsor:
Hopital Foch
Organization:
Hopital Foch
Study Overview
Official Title:
Pilot Study of Lung Transplantation After Ex-Vivo Lung Reconditioning
Status:
COMPLETED
Status Verified Date:
2017-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ExVivo
Brief Summary:
Only about 15 of the potential candidates for lung donation are considered suitable for transplantation Thus a strategy that could improve the quality and precision of assessment of nonacceptable donor lungs could have a major impact on reducing waiting time and mortality while on the list
A new method for ex vivo lung perfusion EVLP has been developed recently by Steen and colleagues to assess the quality of lungs from a non-heart-beating donor The method can also be used to recondition marginal and nonacceptable donor lungs
After harvesting the lungs were perfused ex vivo with Steen Solution an extracellular matrix with high colloid osmotic pressure A membrane oxygenator connected to the circuit received gas from a mixture of nitrogen and carbon dioxide maintaining a normal mixed venous blood gas level in the perfusate The lungs were gradually rewarmed reperfused and ventilated for evaluation through analyses of oxygenation capacity pulmonary vascular resistance PVR lung compliance LC and biopsy
A new method for ex vivo lung perfusion EVLP has been developed recently by Steen and colleagues to assess the quality of lungs from a non-heart-beating donor The method can also be used to recondition marginal and nonacceptable donor lungs
After harvesting the lungs were perfused ex vivo with Steen Solution an extracellular matrix with high colloid osmotic pressure A membrane oxygenator connected to the circuit received gas from a mixture of nitrogen and carbon dioxide maintaining a normal mixed venous blood gas level in the perfusate The lungs were gradually rewarmed reperfused and ventilated for evaluation through analyses of oxygenation capacity pulmonary vascular resistance PVR lung compliance LC and biopsy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2010-A00879-30 | OTHER | ANSM | None |