Ignite Creation Date:
2024-05-05 @ 12:05 PM
Last Modification Date:
2024-10-26 @ 9:19 AM
Study NCT ID:
NCT00231452
Status:
COMPLETED
Last Update Posted:
2011-10-28
First Post:
2005-09-30
Brief Title:
Age of Exposure and Immunity to Malaria in Infants
Sponsor:
Hospital Clinic of Barcelona
Organization:
Hospital Clinic of Barcelona
Study Overview
Official Title:
Age of Exposure and Immunity to Malaria in Infants
Status:
COMPLETED
Status Verified Date:
2011-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall objective is to evaluate the effect of exposure to Plasmodium P falciparum erythrocytic stage antigens during different periods of infancy on the development of naturally acquired immunity NAI
Hypothesis Exposure to P falciparum prior to 5 months of age does not result in the development of NAI while exposure to P falciparum after 5 months of age leads to the development of NAI The risks of clinical malaria and anaemia during the second year of life will be compared between cohorts as well as their correlations with the type and quality of immune responses antibodies to several P falciparum antigens cytokines oxidative stress markers and host genetic factors These results should shed light on the determinants of the development of anti-P falciparum responses early in life and the potential constraints to early life immunisation
Hypothesis Exposure to P falciparum prior to 5 months of age does not result in the development of NAI while exposure to P falciparum after 5 months of age leads to the development of NAI The risks of clinical malaria and anaemia during the second year of life will be compared between cohorts as well as their correlations with the type and quality of immune responses antibodies to several P falciparum antigens cytokines oxidative stress markers and host genetic factors These results should shed light on the determinants of the development of anti-P falciparum responses early in life and the potential constraints to early life immunisation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None