Ignite Creation Date:
2024-05-05 @ 12:05 PM
Last Modification Date:
2024-10-26 @ 9:20 AM
Study NCT ID:
NCT00234299
Status:
COMPLETED
Last Update Posted:
2016-05-25
First Post:
2005-10-04
Brief Title:
Effects of ASA on Prostate Tissue
Sponsor:
University of Washington
Organization:
University of Washington
Study Overview
Official Title:
In Vivo Molecular Effects of Aspirin on Prostate Tissue
Status:
COMPLETED
Status Verified Date:
2016-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aspirin affects many physiological processes through its anti-inflammatory actions Various cancers including prostate cancer appear to utilize inflammatory signals to facilitate their growth and progression
We hypothesize that oral aspirin acts directly on prostate epithelial cells to alter COX-2-related metabolism and inhibit prostate cell growth
We hypothesize that oral aspirin acts directly on prostate epithelial cells to alter COX-2-related metabolism and inhibit prostate cell growth
Detailed Description:
Prostate cancer is the most common non-cutaneous malignancy in men and is the second leading cause of cancer death among US men 221000 new cases and 29000 deaths are expected in 2003 The incidence of prostate cancer diagnosis is increasing at 3 per year Prostate specific antigen PSA screening has resulted in improvements in early diagnosis of prostate cancer However available treatments all may have a significant negative effect on quality of life
Studies have implicated a beneficial association between ASA use and a lower risk of other types of malignancies including stomach esophageal breast ovarian and prostate cancer There is significant evidence to suggest that aspirin has a protective effect against prostate cancer
Studies have implicated a beneficial association between ASA use and a lower risk of other types of malignancies including stomach esophageal breast ovarian and prostate cancer There is significant evidence to suggest that aspirin has a protective effect against prostate cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 28526-V | OTHER | University of Washington HSD | None |
| 05-7956-V 01 | OTHER | None | None |