Ignite Creation Date:
2024-05-06 @ 8:59 AM
Last Modification Date:
2024-10-26 @ 12:08 PM
Study NCT ID:
NCT02879825
Status:
COMPLETED
Last Update Posted:
2022-02-03
First Post:
2016-08-23
Brief Title:
Myocardial Characterization of Arrhythmogenic Mitral Valve Prolapse STAMP STretch and Myocardial Characterization in Arrhythmogenic Mitral Valve Prolapse
Sponsor:
Central Hospital Nancy France
Organization:
Central Hospital Nancy France
Study Overview
Official Title:
Myocardial Characterization of Arrhythmogenic Mitral Valve Prolapse
Status:
COMPLETED
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
STAMP
Brief Summary:
Mitral valve prolapse MVP is a frequent affection of the mitral valve or its sub-valvular apparatus with a prevalence of 2-3 in the general population This valvular disease is generally considered as benign but may at term evolve toward mitral valve regurgitation of various severity andor arrhythmia
Mitral valve prolapse is routinely diagnosed using transthoracic echocardiography and only patients with significant mitral regurgitation will undergo subsequent examination 24-hour external loop recording exercise ECG cardiac MRI and a close follow-up
External loop recording and exercise ECG have an interest in the identification of patients presenting with arrhythmic complications such as premature ventricular contractions and in the global evaluation of hemodynamic consequences of the mitral regurgitation
More recently detection of myocardial fibrosis among patients with MVP and severe ventricular arrhythmia has been identified Fibrosis could evolve independently of the valvular regurgitations severity and could be a substrate myocardial scar leading to ventricular arrhythmia However no study has specifically characterized myocardial lesions among patients with MVP and none or not significant mitral regurgitation Using cardiac magnetic resonance imaging MRI gold standard technique in myocardial imaging and characterization and echocardiography particularly speckle-tracking imaging identification of static fibrosis andor dynamic ventricular systolic deformation patterns using speckle-tracking strain myocardial lesions
Identification of patients with impaired deformation patterns fibrosis or with premature ventricular contractions may isolate a sub-group of patients with a higher risk of severe ventricular arrhythmia for whom a closer follow-up could be justified
Mitral valve prolapse is routinely diagnosed using transthoracic echocardiography and only patients with significant mitral regurgitation will undergo subsequent examination 24-hour external loop recording exercise ECG cardiac MRI and a close follow-up
External loop recording and exercise ECG have an interest in the identification of patients presenting with arrhythmic complications such as premature ventricular contractions and in the global evaluation of hemodynamic consequences of the mitral regurgitation
More recently detection of myocardial fibrosis among patients with MVP and severe ventricular arrhythmia has been identified Fibrosis could evolve independently of the valvular regurgitations severity and could be a substrate myocardial scar leading to ventricular arrhythmia However no study has specifically characterized myocardial lesions among patients with MVP and none or not significant mitral regurgitation Using cardiac magnetic resonance imaging MRI gold standard technique in myocardial imaging and characterization and echocardiography particularly speckle-tracking imaging identification of static fibrosis andor dynamic ventricular systolic deformation patterns using speckle-tracking strain myocardial lesions
Identification of patients with impaired deformation patterns fibrosis or with premature ventricular contractions may isolate a sub-group of patients with a higher risk of severe ventricular arrhythmia for whom a closer follow-up could be justified
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None