Ignite Creation Date:
2024-05-06 @ 8:57 AM
Last Modification Date:
2024-10-26 @ 12:07 PM
Study NCT ID:
NCT02860793
Status:
COMPLETED
Last Update Posted:
2016-08-10
First Post:
2016-08-02
Brief Title:
Role of PTK-7 in Acute Myeloid Leukemias
Sponsor:
Institut Paoli-Calmettes
Organization:
Institut Paoli-Calmettes
Study Overview
Official Title:
Role of PTK-7 in Acute Myeloid Leukemias Impact of PTK7 Serum Marker and ex Vivo Studies to Decipher the Role of PTK7
Status:
COMPLETED
Status Verified Date:
2016-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LAM-PTK7
Brief Summary:
The pseudo tyrosine kinase receptor 7 PTK7 is an orphan tyrosine kinase receptor assigned to the planar cell polarity pathway PTK7 is expressed in normal myeloid progenitors and CD34 CD38- bone marrow cells in humans It is also expressed in acute myeloid leukemia AML and is mostly assigned to granulocytic lineage differentiation In AML PTK7 seems to convey promigratory and antiapoptotic signals into the cell and represents an independent prognosis factor of survival in patients treated with induction chemotherapy This study aims at
evaluating the impact of PTK7 expression on primary AML cells ex vivo
evaluating the diagnostic and prognostic value of a soluble form of PTK7
evaluating the impact of PTK7 expression on primary AML cells ex vivo
evaluating the diagnostic and prognostic value of a soluble form of PTK7
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None