Ignite Creation Date:
2024-05-06 @ 8:54 AM
Last Modification Date:
2024-10-26 @ 12:06 PM
Study NCT ID:
NCT02847312
Status:
UNKNOWN
Last Update Posted:
2016-07-28
First Post:
2016-07-25
Brief Title:
Chronic Cardiovascular and Gut-bacteria Effects of Phenolic Rich Oats in Adults With Above Average Blood Pressure
Sponsor:
University of Reading
Organization:
University of Reading
Study Overview
Official Title:
Chronic Cardiovascular and Gut-bacteria Effects of Phenolic Rich Oats in Adults With Above Average Blood Pressure
Status:
UNKNOWN
Status Verified Date:
2016-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this proposed human trial the investigators aim to establish whether 4 weeks of daily consumption of beta-glucan matched meals providing either a high dose or a moderate dose of oat avenanthramides and phenolic acids leads to dose-dependent chronic improvements in markers of CVD risk and gut health relative to an energy matched control intervention in healthy adults with above average blood pressure
Detailed Description:
To investigate the chronic effects of daily intake of oat products on flow mediated dilatation of the brachial artery FMD primary endpoint microvascular endothelial function measured by laser Doppler iontophoresis pulse wave analysis gut microbiota diversity 24h blood pressure activity of the renin angiotensin system markers related to cellular production of nitric oxide and reactive oxygen species inflammatory cytokines and further potentially emerging biochemical markers of CVD risk
To establish if phenolic acids and avenanthramides from oat products exert cardiovascular and microbial effects in a dose dependent manner
To measure urinary and fecal excretion of avenanthramide and phenolic acid metabolites
To explore correlations between bacterial population changes and CVD risk markers
To establish if phenolic acids and avenanthramides from oat products exert cardiovascular and microbial effects in a dose dependent manner
To measure urinary and fecal excretion of avenanthramide and phenolic acid metabolites
To explore correlations between bacterial population changes and CVD risk markers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None