Ignite Creation Date:
2024-05-06 @ 8:52 AM
Last Modification Date:
2024-10-26 @ 12:06 PM
Study NCT ID:
NCT02845167
Status:
COMPLETED
Last Update Posted:
2016-07-27
First Post:
2016-07-17
Brief Title:
Effect of Preoperative Exercise on Postoperative Outcome in AAA Patients Pilot Study
Sponsor:
Medway NHS Foundation Trust
Organization:
Medway NHS Foundation Trust
Study Overview
Official Title:
The Effect of Preoperative Exercise on Postoperative Outcome in AAA Patients Pilot Study
Status:
COMPLETED
Status Verified Date:
2016-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Basic animal research has demonstrated that exercise training can protect the myocardium from ischemia-reperfusion injury through several biological mechanisms This effect of exercise training may be beneficial in the perioperative period when cardiac complications may arise However exercise induced cardioprotection is lost completely within 18 days of stopping the training program This finding from animal research will be used to test the hypothesis that 3 days of consecutive exercise with the last bout conducted within the last 2448 hours prior to surgery will have a cardioprotective effect Specifically exercise has been shown to protect cardiac myocytes against reperfusion induced oxidative stress and mitochondria against reperfusion induced damage This exercise mediated cardioprotection is observed in short moderate duration ischemia ie 5-20 min and moderate to severe ie20-60 min ischemic insults The effects of exercise induced cardioprotection have only been investigated at cell level and it has not been shown whether this will translate into a reduction in postsurgical reperfusion injury and associated complications To study this potential cardioprotective effect the investigators will aim to recruit patients who have a high risk of receiving reperfusion injury during surgery Specifically the investigators will recruit abdominal aortic aneurysm patients where the risk of heart complications is high There is also currently no evidence in the published literature with regard to the effect of preoperative supervised exercise
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None