Ignite Creation Date:
2024-05-06 @ 8:52 AM
Last Modification Date:
2024-10-26 @ 12:06 PM
Study NCT ID:
NCT02848534
Status:
COMPLETED
Last Update Posted:
2018-08-10
First Post:
2016-07-26
Brief Title:
The Value of the Neutrophil to Lymphocyte Ratio in the Diagnosis of Bacterial Infections
Sponsor:
Centre Hospitalier Universitaire Amiens
Organization:
Centre Hospitalier Universitaire Amiens
Study Overview
Official Title:
The Value of the Neutrophil to Lymphocyte Ratio in the Diagnosis of Bacterial Infections
Status:
COMPLETED
Status Verified Date:
2018-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RNL-MI
Brief Summary:
The gold standard for diagnosing a bacterial infection is isolation of the pathogenic germ which is not easy in routine clinical practice
Conventional markers do not have sufficient diagnostic value for making a rapid diagnosis on admission A 2004 literature calculated the diagnostic values of C-reactive protein CRP and procalcitonin PCT levels for the diagnosis of bacterial infections relative to other causes of inflammation For CRP the sensitivity was 75 95 CI 62-84 and the specificity was 67 95 CI 56-77 For PCT the sensitivity was 88 95 CI 62-84 and the specificity was 81 95 CI 67-90
The first cellular immune response to infection consists of the mobilization of polynuclear neutrophils from the bone marrow to the infection site under the effect of pre-inflammatory cytokines as well as the apoptosis of lymphocytes and their sequestration at the infection site This results in lymphopenia and the elevated polynuclear neutrophil count PNN observed in bacterial infections
Hence it is legitimate to hypothesize that the neutrophil to lymphocyte ratio NLR can be used in the diagnosis of bacterial infection This ratios value in the diagnosis of sepsis in the emergency department was studied and the researchers found higher diagnostic values than for CRP and PCT
The NLRs potential value in the diagnosis of a bacterial infection in a context of fever or hyperthermia regardless of the presence or absence of bacteraemia has not been studied before This ratio could also be compared with standard biomarkers CRP and PCT levels the white blood cell count and the PNN
Conventional markers do not have sufficient diagnostic value for making a rapid diagnosis on admission A 2004 literature calculated the diagnostic values of C-reactive protein CRP and procalcitonin PCT levels for the diagnosis of bacterial infections relative to other causes of inflammation For CRP the sensitivity was 75 95 CI 62-84 and the specificity was 67 95 CI 56-77 For PCT the sensitivity was 88 95 CI 62-84 and the specificity was 81 95 CI 67-90
The first cellular immune response to infection consists of the mobilization of polynuclear neutrophils from the bone marrow to the infection site under the effect of pre-inflammatory cytokines as well as the apoptosis of lymphocytes and their sequestration at the infection site This results in lymphopenia and the elevated polynuclear neutrophil count PNN observed in bacterial infections
Hence it is legitimate to hypothesize that the neutrophil to lymphocyte ratio NLR can be used in the diagnosis of bacterial infection This ratios value in the diagnosis of sepsis in the emergency department was studied and the researchers found higher diagnostic values than for CRP and PCT
The NLRs potential value in the diagnosis of a bacterial infection in a context of fever or hyperthermia regardless of the presence or absence of bacteraemia has not been studied before This ratio could also be compared with standard biomarkers CRP and PCT levels the white blood cell count and the PNN
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None