Ignite Creation Date:
2024-05-06 @ 8:52 AM
Last Modification Date:
2024-10-26 @ 12:06 PM
Study NCT ID:
NCT02846025
Status:
COMPLETED
Last Update Posted:
2016-08-01
First Post:
2016-07-15
Brief Title:
Profile Of Methylation and Gene Expression Of Gene ADRB3 And Effects Of Folate Intake
Sponsor:
Federal University of Paraíba
Organization:
Federal University of Paraíba
Study Overview
Official Title:
Profile Of Methylation and Gene Expression Of Gene ADRB3 And Effects Of Ingestion Of Folate Hazelnuts And Diets Oil Capsule Antioxidants In Case Inflammatory
Status:
COMPLETED
Status Verified Date:
2016-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
ABSTRACT
Epigenetic mechanisms may be involved in the regulation of lipid metabolism and inflammatory markers may therefore contribute to the cardiovascular risk profile as well as environmental factors have a significant impact on the epigenetic program of gene expression Methyl groups are usually added or removed as needed and can be influenced by diet soon dietary factors have been linked to the change of DNA methylation resulting in changes in gene expression Research on the prevalence of gene methylation levels on the impact of nutrient intake as well as the inflammatory condition and the results of dietary interventions for the genes it is a sparse area in studies and therefore expanding of the knowledge Thus understanding the effects of a diet rich in antioxidants and hazelnut oil in inflammation and DNA methylation profile is important because chronic diseases with cardiovascular disease can begin with the consumption of modified lipids and can research this stage provide important dietary allowances for the development of this disease prevention strategies even in adulthood This PhD project is linked to a larger project entitled II Diagnosis Cycle and Intervention Food Situation Nutrition and Noncommunicable Diseases Prevalent over the City Population of João Pessoa PB II DISANDNT PB and have two methodological designs the first one is the composition of a representative sample of adults in the city of João Pessoa from II DISANDNT JP population-based study and cross-sectional The second methodological design was developed with a subsample of the above population selected from criteria being the type and interventional clinical trial This model will have to evaluate the effect of a diet rich in antioxidant and hazelnut oil in inflammation and gene expression
Epigenetic mechanisms may be involved in the regulation of lipid metabolism and inflammatory markers may therefore contribute to the cardiovascular risk profile as well as environmental factors have a significant impact on the epigenetic program of gene expression Methyl groups are usually added or removed as needed and can be influenced by diet soon dietary factors have been linked to the change of DNA methylation resulting in changes in gene expression Research on the prevalence of gene methylation levels on the impact of nutrient intake as well as the inflammatory condition and the results of dietary interventions for the genes it is a sparse area in studies and therefore expanding of the knowledge Thus understanding the effects of a diet rich in antioxidants and hazelnut oil in inflammation and DNA methylation profile is important because chronic diseases with cardiovascular disease can begin with the consumption of modified lipids and can research this stage provide important dietary allowances for the development of this disease prevention strategies even in adulthood This PhD project is linked to a larger project entitled II Diagnosis Cycle and Intervention Food Situation Nutrition and Noncommunicable Diseases Prevalent over the City Population of João Pessoa PB II DISANDNT PB and have two methodological designs the first one is the composition of a representative sample of adults in the city of João Pessoa from II DISANDNT JP population-based study and cross-sectional The second methodological design was developed with a subsample of the above population selected from criteria being the type and interventional clinical trial This model will have to evaluate the effect of a diet rich in antioxidant and hazelnut oil in inflammation and gene expression
Detailed Description:
This thesis is linked to a population-based survey entitled Diagnosis II Cycle and Intervention Food Situation Nutrition and Noncommunicable Diseases Prevalent over the city of João Pessoa Population PB II DISANDNT PB
For realization of this thesis a first population-based study representative of adults in the east areas and west of the city of João Pessoa there was the calculation of a representative sample for the age group of adults using information provided by the city as map the municipality the number of blocks per district and the Brazilian Institute of Geography and Statistics
Home visits and implementation of the survey questionnaires were carried out by teams of undergraduate researchers from the Nutrition courses masters and doctoral students of the Post Graduate Program in Nutrition Sciences PPGCN UFPB duly previously trained at the beginning of data collection after the pilot study and following
The trained teams after recognizing the drawn court were instructed to select all households in the court The blocks that did not have homes the homes in which those responsible have not accepted to participate and the amount of individuals who refused to participate in randomly selected households were computed and resorteadas randomly thereafter to minimize losses
In each residence drawn all individuals adults aged between 20-59 years were invited to participate in the research through application of socioeconomic and demographic characteristics questionnaires epidemiological characterization nutritional assessment and food intake biochemical evaluation and brands epigenetic
For realization of this thesis a first population-based study representative of adults in the east areas and west of the city of João Pessoa there was the calculation of a representative sample for the age group of adults using information provided by the city as map the municipality the number of blocks per district and the Brazilian Institute of Geography and Statistics
Home visits and implementation of the survey questionnaires were carried out by teams of undergraduate researchers from the Nutrition courses masters and doctoral students of the Post Graduate Program in Nutrition Sciences PPGCN UFPB duly previously trained at the beginning of data collection after the pilot study and following
The trained teams after recognizing the drawn court were instructed to select all households in the court The blocks that did not have homes the homes in which those responsible have not accepted to participate and the amount of individuals who refused to participate in randomly selected households were computed and resorteadas randomly thereafter to minimize losses
In each residence drawn all individuals adults aged between 20-59 years were invited to participate in the research through application of socioeconomic and demographic characteristics questionnaires epidemiological characterization nutritional assessment and food intake biochemical evaluation and brands epigenetic
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None