Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004356
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Study of Homocysteine Metabolism in Homocystinuria
Sponsor:
National Center for Research Resources NCRR
Organization:
Office of Rare Diseases ORD
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Determine basal and postmethionine plasma homocysteine in patients with premature vascular disease cystathionine beta-synthase CBS or methylenetitrahydrofolate reductase MTHFR deficiency and in obligate heterozygotes for CBS or MTHFR
II Determine whole-body homocysteine metabolic rates with isotopically-labeled methionine
II Determine whole-body homocysteine metabolic rates with isotopically-labeled methionine
Detailed Description:
PROTOCOL OUTLINE This is a two-part study of homocysteine metabolism Age-matched normal controls are entered in both parts of the study
In first part of the study participants are given oral methionine baseline and postmethionine studies include amino acid quantitation analysis of rapidly deproteinized plasma and total plasma homocysteine
In the second part of the study participants men and postmenopausal women only undergo methionine tracer studies
In first part of the study participants are given oral methionine baseline and postmethionine studies include amino acid quantitation analysis of rapidly deproteinized plasma and total plasma homocysteine
In the second part of the study participants men and postmenopausal women only undergo methionine tracer studies
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UCSD-1033 | None | None | None |