Ignite Creation Date:
2024-05-06 @ 8:48 AM
Last Modification Date:
2024-10-26 @ 12:05 PM
Study NCT ID:
NCT02828137
Status:
COMPLETED
Last Update Posted:
2016-08-22
First Post:
2016-06-30
Brief Title:
Relation Between NLR and IMR in STEMI Patients
Sponsor:
Inha University Hospital
Organization:
Inha University Hospital
Study Overview
Official Title:
Relationships Between Neutrophil-to-Lymphocyte Ratio and Index of Microcirculatory Resistance in ST-segment Elevation Myocardial Infarction Patients Undergone Primary Percutaneous Coronary Intervention
Status:
COMPLETED
Status Verified Date:
2016-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The neutrophil-to-lymphocyte ratio NLR has been proven to be reliable inflammatory marker for atherosclerotic process and predictor for clinical outcomes in patients with various cardiovascular diseases Recent study reported elevated NLR was associated with impaired myocardial perfusion in ST-segment elevation myocardial infarction STEMI patients The investigators sought to determine whether NLR is associated with coronary microcirculation assessed by index of microcirculatory resistance IMR in STEMI patients who undergone primary percutaneous coronary intervention PCI A total of 123 patients with STEMI underwent successful primary PCI were consecutively enrolled NLR at admission was calculated and the patients were divided into three groups according to NLR tertiles IMR was measured by intracoronary thermodilution-derived method immediately after index PCI
Detailed Description:
A total of 123 consecutive STEMI patients who underwent successful primary PCI and coronary physiologic study immediately after PCI were retrospectively enrolled in the study All patients underwent index PCI between May 2009 and October 2014 at INHA university hospital The definition of STEMI was determined by the current guidelines
Complete blood counts including total and differential WBC counts were obtained at the time of admission Total counts of WBC neutrophils and lymphocytes were assessed using an automated blood cell counter XE-2100 Sysmex Inc Japan NLR was calculated as the ratio of the neutrophil counts to the lymphocyte counts All patients were divided into 3 groups according to the NLR tertiles
The IMR was assessed shortly after primary PCI by using thermodilution-derived method After successful interventional reperfusion intracoronary nitroglycerin 100200μg was administered and coronary pressure guidewire Radi Pressure Wire 5 Radi Medical Systems Uppsala Sweden was calibrated outside the patient The guidewire was equalized at the distal tip of guiding catheter and then advanced towards the distal third of infarct related artery IRA Three times of saline injection 35 ml were administered to IRA and baseline mean transit time was assessed Microcirculatory hyperemia was induced by using an adenosine infusion 140 μgkgmin administered via peripheral venous line During maximal hyperemia hyperemic mean transit time Tmn was measured using same method as prior separate saline injections Mean aortic Pa and distal coronary pressures Pd was measured during hyperemia The IMR was calculated the formula as follows IMR Pd x hyperemic Tmn Fractional flow reserve FFR was calculated by ratio of Pd to Pa during maximal hyperemic status Coronary flow reserve CFR was derived from dividing the resting Tmn by hyperemic Tmn
Continuous variables were presented as mean standard deviation SD and categorical variables as the number of patients percentages The one way analysis of variance ANOVA was used for comparing continuous variables Additionally post-hoc analysis was performed for evaluating to be significant by ANOVA The Pearsons chi-square test or Fishers exact test was used for analyzing categorical variables Linear regression analysis was performed for investigating the association between NLR and variables using clinical laboratory echocardiographic and angiographic data A p value 005 was regarded statistically significant All statistical analyses were carried out with SPSS version 190 SPSS inc Chicago Illinois USA
Complete blood counts including total and differential WBC counts were obtained at the time of admission Total counts of WBC neutrophils and lymphocytes were assessed using an automated blood cell counter XE-2100 Sysmex Inc Japan NLR was calculated as the ratio of the neutrophil counts to the lymphocyte counts All patients were divided into 3 groups according to the NLR tertiles
The IMR was assessed shortly after primary PCI by using thermodilution-derived method After successful interventional reperfusion intracoronary nitroglycerin 100200μg was administered and coronary pressure guidewire Radi Pressure Wire 5 Radi Medical Systems Uppsala Sweden was calibrated outside the patient The guidewire was equalized at the distal tip of guiding catheter and then advanced towards the distal third of infarct related artery IRA Three times of saline injection 35 ml were administered to IRA and baseline mean transit time was assessed Microcirculatory hyperemia was induced by using an adenosine infusion 140 μgkgmin administered via peripheral venous line During maximal hyperemia hyperemic mean transit time Tmn was measured using same method as prior separate saline injections Mean aortic Pa and distal coronary pressures Pd was measured during hyperemia The IMR was calculated the formula as follows IMR Pd x hyperemic Tmn Fractional flow reserve FFR was calculated by ratio of Pd to Pa during maximal hyperemic status Coronary flow reserve CFR was derived from dividing the resting Tmn by hyperemic Tmn
Continuous variables were presented as mean standard deviation SD and categorical variables as the number of patients percentages The one way analysis of variance ANOVA was used for comparing continuous variables Additionally post-hoc analysis was performed for evaluating to be significant by ANOVA The Pearsons chi-square test or Fishers exact test was used for analyzing categorical variables Linear regression analysis was performed for investigating the association between NLR and variables using clinical laboratory echocardiographic and angiographic data A p value 005 was regarded statistically significant All statistical analyses were carried out with SPSS version 190 SPSS inc Chicago Illinois USA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None