Ignite Creation Date:
2024-05-05 @ 10:23 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001154
Status:
COMPLETED
Last Update Posted:
2024-07-15
First Post:
1999-11-03
Brief Title:
Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Lipoprotein Metabolism in Normal Volunteers and Hyperlipoproteinemic Patients
Status:
COMPLETED
Status Verified Date:
2024-06-28
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Researchers plan to study the fat-rich particles called lipoproteins which circulate in the blood This study is designed to improve understanding of normal as well as abnormal lipoprotein metabolism and the role it plays in the development of hardening of the arteries atherosclerosis
Patients participating in this study will receive injections of lipoproteins or apolipoproteins the protein component of lipoproteins that have been isolated and purified These lipoproteins will be labeled with small amounts of radioactive material and sterilized before they are injected into the patient
Patients participating in the study will be required to have blood samples taken and provide urine samples throughout the course of the study In addition patient will be required to follow a specially formulated diet Patients will be weighed throughout the course of the study
Patients participating in this study will receive injections of lipoproteins or apolipoproteins the protein component of lipoproteins that have been isolated and purified These lipoproteins will be labeled with small amounts of radioactive material and sterilized before they are injected into the patient
Patients participating in the study will be required to have blood samples taken and provide urine samples throughout the course of the study In addition patient will be required to follow a specially formulated diet Patients will be weighed throughout the course of the study
Detailed Description:
We propose to investigate human in vivo lipoprotein metabolism using radiolabeled apolipoproteins on plasma lipoproteins Paired kinetic studies using dual-labeled iodinated lipoproteins and apolipoproteins are performed in healthy volunteer controls with normal lipids and subjects with dyslipidemia under controlled metabolic conditions Studies are designed to formulate metabolic pathways in patients with undefined genetic disorders of lipid metabolism as well as in healthy volunteers to provide original insights into normal and pathologic metabolic pathways All kinetic data is computer analyzed to provide quantitative data and facilitate direct comparison of multiple studies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 76-H-0051 | None | None | None |