Ignite Creation Date:
2024-05-06 @ 8:48 AM
Last Modification Date:
2024-10-26 @ 12:05 PM
Study NCT ID:
NCT02826408
Status:
COMPLETED
Last Update Posted:
2018-03-13
First Post:
2016-07-05
Brief Title:
Effect of Proton Pump Inhibitors on Palpitations
Sponsor:
Jordan Collaborating Cardiology Group
Organization:
Jordan Collaborating Cardiology Group
Study Overview
Official Title:
A Randomized Placebo Controlled Trial on the Effect of Proton Pump Inhibitors on Palpitations With no Apparent Cause to Explain Such a Symptom
Status:
COMPLETED
Status Verified Date:
2018-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Palpitation is a common complaint Patients frequently feel this symptom despite having normal rhythm during symptoms I have seen many patients who improve significantly on treatment with proton pump inhibitors PPI It may be that gastritis provokes a feeling of discomfort that subsequently starts the feeling of palpitation On searching literature I found no study that investigated the effect of PPIs on palpitations Therefore I propose a study where the investigators randomize people with palpitations with normal heart rate no arrhythmia and no apparent cause such as anxiety or clear illness to receive either PPI or placebo The result will help to investigate if the improvement is true and if the results are positive this can provide a simple treatment for a common problem
Detailed Description:
Methods Two hundred patients with palpitations and no clear cause for their symptoms will be randomized to receive either PPI or placebo for one month At base line they will be investigated to rule out arrhythmia by documenting normal heart rate less than 110 beat per minute or ECG showing normal sinus rhythm or mild sinus tachycardia Less than 110 per minute during symptoms Obvious causes such as anxiety due to a stressful event or organic causes such anemia or thyroid disorders should be also ruled out
Patient who agree to participate in the study will be asked to sign an informed consent A baseline questionnaire with symptoms will be filled They will then be randomized for treatment with either PPI or placebo once at night time After 10 days of treatment they will be contacted and questioned regarding their symptoms The two groups will be compared to see if there is any improvement of symptoms with treatment
Studying group The study will be under the umbrella of the JCC group Primary investigators are Dr Munir Zaqqa and Dr Ismail Hamam
Support required Pharmaceutical company will be contacted to provide 120 packets with 30 tabs of PPI and if possible packets with similar matching placebo to support the study
Study criteria inclusion
1 Persons with palpitations and no clear cause who are above the age of 16 years and who consent to the study will be included
2 Clear causes that should be excluded are true arrhythmia such SVT or VT or frequent premature atrial or ventricular contractions or any organic cause such as thyroid disorder anemia hg less than 11 gdl and obvious anxiety disorder
3 Arrhythmia can be excluded by an ECG showing sinus rhythm or sinus tachycardia during episodes or measurement of heart rate by a reliable method during symptoms showing regular heart rate less than 120 beats per minute
4 Patient will be randomized to either PPI or placebo to be taken one table at night time
5 Patients will be provided with 2 weeks supply but will be evaluated at 10 days to see if symptoms improved
6 The two groups will be compared using statistical methods to see if there is difference in improvement
Expected harm
PPIs are generally safe medications Side effects are rare and generally mild They include nausea stomach pain diarrhea constipation or headache
Very rarely allergic reaction can occur with hives difficulty in breathing and swelling of the face and lips
Benefit to the patient
Patients randomized to either group may experience benefit due to the medication or even placebo use There is no financial benefit of participating in the study The result of the study will be used to help patient in the future with similar symptoms
Patient who agree to participate in the study will be asked to sign an informed consent A baseline questionnaire with symptoms will be filled They will then be randomized for treatment with either PPI or placebo once at night time After 10 days of treatment they will be contacted and questioned regarding their symptoms The two groups will be compared to see if there is any improvement of symptoms with treatment
Studying group The study will be under the umbrella of the JCC group Primary investigators are Dr Munir Zaqqa and Dr Ismail Hamam
Support required Pharmaceutical company will be contacted to provide 120 packets with 30 tabs of PPI and if possible packets with similar matching placebo to support the study
Study criteria inclusion
1 Persons with palpitations and no clear cause who are above the age of 16 years and who consent to the study will be included
2 Clear causes that should be excluded are true arrhythmia such SVT or VT or frequent premature atrial or ventricular contractions or any organic cause such as thyroid disorder anemia hg less than 11 gdl and obvious anxiety disorder
3 Arrhythmia can be excluded by an ECG showing sinus rhythm or sinus tachycardia during episodes or measurement of heart rate by a reliable method during symptoms showing regular heart rate less than 120 beats per minute
4 Patient will be randomized to either PPI or placebo to be taken one table at night time
5 Patients will be provided with 2 weeks supply but will be evaluated at 10 days to see if symptoms improved
6 The two groups will be compared using statistical methods to see if there is difference in improvement
Expected harm
PPIs are generally safe medications Side effects are rare and generally mild They include nausea stomach pain diarrhea constipation or headache
Very rarely allergic reaction can occur with hives difficulty in breathing and swelling of the face and lips
Benefit to the patient
Patients randomized to either group may experience benefit due to the medication or even placebo use There is no financial benefit of participating in the study The result of the study will be used to help patient in the future with similar symptoms
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None