Ignite Creation Date:
2024-05-06 @ 8:48 AM
Last Modification Date:
2024-10-26 @ 12:05 PM
Study NCT ID:
NCT02829476
Status:
COMPLETED
Last Update Posted:
2017-05-12
First Post:
2016-07-04
Brief Title:
Ghrelin Resistance in Adolescents With Idiopathic Scoliosis
Sponsor:
University Hospital Toulouse
Organization:
University Hospital Toulouse
Study Overview
Official Title:
Ghrelin Cellular Resistance Study in Adolescents With Idiopathic Scoliosis
Status:
COMPLETED
Status Verified Date:
2017-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Adolescent idiopathic Scoliosis AIS is the most common spine pathology It is opposed to secondary scoliosis due to chronic diseases Many hypotheses have been made to elucidate the origin of this illness Recently the melatonin pathway has been investigated as pinealectomy of the chicken creates a scoliosis that resembles AIS and melatonin supplementation reverses the process In addition administration of melatonin to AIS patients improved the pathology However this hypothesis has shown controversial results Recent studies have demonstrated melatonin cellular resistance in osteoblastic cells from AIS patients Melatonin acts through G protein coupled receptor GPCR mainly using the Gi pathway In AIS osteoblasts this pathway is blocked leading to a decrease in the inactivation of the adenylyl cyclase and therefore maintenance of high level of cyclic adenosine monophosphate cAMP concentrations in the cells As modulation of cAMP is important for osteogenesis such resistance may be critical for the initiation or the development of AIS
Gi signalization is used by several other GPCR thus this hormonal resistance could logically be found in other hormonal or mediator pathways A precedent study previously focused on ghrelin in AIS and demonstrated that AIS patients possess elevated plasmatic values of ghrelin This study also observed decreased response to ghrelin in AIS cultures osteoblasts
Gi signalization is used by several other GPCR thus this hormonal resistance could logically be found in other hormonal or mediator pathways A precedent study previously focused on ghrelin in AIS and demonstrated that AIS patients possess elevated plasmatic values of ghrelin This study also observed decreased response to ghrelin in AIS cultures osteoblasts
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Local Grant 2009 | OTHER_GRANT | 0916002 | None |